Fig. 2

A Time-activity curves in the whole brain, expressed in standard uptake value (SUV) after administration of [¹⁸F]DPA-714 to 5xFAD mice at the age of 4, 8, and 12 months. B–D Box plots representing distribution volume ratios (DVRs) in the cortex, hippocampus, and thalamus, obtained by Regional Logan Plot analysis (the cerebellum as the reference region). “*” depicts the difference between groups at each time point and “#” depicts the difference within group with respect to the starting time point (4 months). Probability values are depicted as * (P < 0.05), ** (P < 0.01), *** (P < 0.001), and **** (P < 0.0001). E PET images (representative axial slices) obtained in AD and WT animals after intravenous administration of [¹⁸F]DPA-714 at different ages. Images have been generated by dividing, voxel-by-voxel, averaged images (last three frames) by the average value of the concentration of radioactivity in the cerebellum (SUVr), considered as the reference region