β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

Table 4 Relationships between nEV Aβ₄₂ and regional AV45 SUVR

		Total participants	Aβ− NCs	Aβ+ NCs	aMCI plus ADD
L_temporal lobe	R	0.4618	0.0490	0.4178	0.2751
L_temporal lobe	p	0.0000	0.6678	0.0005	0.2544
R_temporal lobe	R	0.5493	0.0770	0.5383	0.5156
R_temporal lobe	p	0.0000	0.5000	0.0000	0.0239
L_parietal lobe	R	0.5699	0.0332	0.4662	0.6309
L_parietal lobe	p	0.0000	0.7715	0.0001	0.0038
R_parietal lobe	R	0.6029	0.1266	0.4573	0.7577
R_parietal lobe	p	0.0000	0.2662	0.0001	0.0002
L_frontal lobe	R	0.5808	0.0815	0.5514	0.7901
L_frontal lobe	p	0.0000	0.4751	0.0000	0.0001
R_frontal lobe	R	0.6043	0.1555	0.5214	0.7979
R_frontal lobe	p	0.0000	0.1713	0.0000	0.0000
L_Pre	R	0.5492	− 0.0356	0.4839	0.4321
L_Pre	p	0.0000	0.7558	0.0000	0.0647
R_Pre	R	0.5359	− 0.0051	0.4701	0.4264
R_Pre	p	0.0000	0.9645	0.0001	0.0687
L_ACC	R	0.5396	− 0.0318	0.5702	0.2565
L_ACC	p	0.0000	0.7812	0.0000	0.2891
R_ACC	R	0.5074	0.0570	0.5480	0.3642
R_ACC	p	0.0000	0.6181	0.0000	0.1253
L_PCC	R	0.4744	0.0901	0.4891	0.3325
L_PCC	p	0.0000	0.4299	0.0000	0.1643
R_PCC	R	0.2522	0.0292	0.0430	0.2076
R_PCC	p	0.0009	0.7983	0.7317	0.3938
L_Ent	R	0.4441	− 0.0206	0.3807	0.3183
L_Ent	p	0.0000	0.8571	0.0016	0.1841
R_Ent	R	0.4927	0.0240	0.4267	0.5008
R_Ent	p	0.0000	0.8334	0.0004	0.0290
L_HP	R	0.0344	0.0007	− 0.2287	0.2958
L_HP	p	0.6563	0.9953	0.0647	0.2188
R_HP	R	0.0599	− 0.0455	− 0.1864	0.2974
R_HP	p	0.4377	0.6904	0.1339	0.2162

The partial correlation analyses between nEV Aβ₄₂ and regional AV45 SUVR were performed in all participants (n = 179), Aβ− NCs (n = 84), Aβ+ NCs (n = 72), and aMCI plus ADD individuals (n = 23), with correction for age, sex, and APOE ε4 status; the correlation coefficients and p values are listed
Abbreviations: Aβ β-amyloid, NCs cognitively normal controls, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, APOE apolipoprotein E, nEV neuronal-derived extracellular vesicle, AV45 [¹⁸F]florbetapir, SUVR standardized uptake value ratio, Pre precuneus, ACC anterior cingulate cortex, PCC posterior cingulate cortex, Ent entorhinal cortex, HP hippocampus

ISSN: 1758-9193