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Table 3 Relationships between nEV Aβ42 and AV45 SUVR

From: β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

 

β

Standard error

Standard β

t

p

The plasma nEV Aβ42 term alone explained 41.1% variation in average AV45 uptake

Intercept

1.109

0.011

 

104.429

< 0.001

nEV Aβ42

0.028

0.003

0.641

10.921

< 0.001

The plasma nEV Aβ42 plus clinical features explained 46.4% variation in average AV45 uptake

Intercept

0.939

0.071

 

13.225

< 0.001

nEV Aβ42

0.025

0.003

0.573

9.695

< 0.001

Age

0.003

0.001

0.154

2.691

0.008

Female

− 0.011

0.015

− 0.043

− 0.763

0.447

APOE ε4 status

0.041

0.015

0.165

2.819

0.005

The plasma nEV Aβ42 plus clinical features and the interaction term explained 46.6% variation in average AV45 uptake

Intercept

0.915

0.077

 

11.986

< 0.001

nEV Aβ42

0.029

0.005

0.651

5.986

< 0.001

Age

0.003

0.001

0.166

2.815

0.005

Female

− 0.01

0.015

− 0.039

− 0.691

0.491

APOE ε4 status

0.055

0.022

0.221

2.517

0.013

nEV Aβ42 * APOE ε4 status

− 0.005

0.006

− 0.121

− 0.858

0.392

  1. The analysis was performed in total individuals including Aβ− NCs, Aβ+ NCs, and patients with aMCI and ADD. In the first model, nEV Aβ42 was used as a predictor of AV45 SUVR; in the second model, nEV Aβ42 plus age, sex, and APOE ε4 status were used as predictors of AV45 SUVR; in the third model, the interaction term between nEV Aβ42 and APOE ε4 status was additionally included
  2. Abbreviations: β-amyloid, NCs cognitively normal controls, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, APOE apolipoprotein E, nEV neuronal-derived extracellular vesicle, AV45 [18F]florbetapir