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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

Fig. 4

Associations of nEV Aβ42 concentrations with cognitive scales and brain regional volume. Correlation analysis was performed between the nEV Aβ42 concentrations and baseline MMSE scores (A) and the nEV Aβ42 concentrations and baseline Ent volume (C). Volume analysis was performed in 192 subjects who had baseline sMRI assessments, including 75 Aβ− NCs, 62 Aβ+ NCs, 27 aMCI, and 28 ADD individuals. Volume was expressed as the ratio to TIV. B Plots show the subset who had follow-up cognitive assessments (104 subjects including 49 Aβ− NCs, 33 Aβ+ NCs, 14 aMCI, and 8 ADD, with an average follow-up time of 14.58 ± 6.37 months). Correlation analysis was performed between the nEV Aβ42 concentrations and longitudinal changes in MMSE scores. D Correlation analysis was performed between the baseline nEV Aβ42 concentrations and longitudinal changes in Ent volume. The longitudinal volume changes were annualized and expressed as the ratio to TIV (multiplied by 104), and the analyses were performed in 88 subjects who had follow-up sMRI assessments, including 43 Aβ− NCs, 31 Aβ+ NCs, 11 aMCI, and 3 ADD individuals, at an average follow-up time of 13.26 ± 4.7 months. The correlation coefficients and p values are listed. Aβ, β-amyloid; NCs, cognitively normal controls; aMCI, amnestic mild cognitive impairment; ADD, Alzheimer’s disease dementia; nEV, neuronal-derived extracellular vesicle; MMSE, mini-mental state examination; Ent, entorhinal cortex; TIV, total intracranial volume; sMRI, structural magnetic resonance imaging

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