Fig. 1From: β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosisnEV Aβ concentrations in different diagnostic groups and ROC curves. Analyses performed after correcting the particle numbers to 3 × 108 for nEV Aβ40 (A) and nEV Aβ42 (B). C The ratio of Aβ42 to Aβ40 among the different diagnostic groups. Statistical analysis was conducted using the Kruskal–Wallis H test, followed by multiple post hoc comparisons (adjusted p value). Comparisons among the groups: *p < 0.05; **p < 0.01; ***p < 0.001; ns, > 0.05. Furthermore, correlation analysis was performed between Aβ42 and Aβ40 (D), and the correlation coefficients and p values are listed. E ROC curves used to distinguish Aβ− NCs from Aβ+ NCs (red), aMCI (green), and ADD (blue) using nEV Aβ42 levels. F We attempted to use different combinations to distinguish Aβ− NCs from Aβ+ NCs. AUC and its corresponding 95% CIs and different diagnostic combinations are listed. All outliers were excluded; outliers were defined as less than Q1 − 2.5 × IQR or greater than Q3 + 2.5 × IQR. Aβ, β-amyloid; NCs, cognitively normal controls; aMCI, amnestic mild cognitive impairment; ADD, Alzheimer’s disease dementia; nEV, neuronal-derived extracellular vesicle; AUC, area under the curve; ROC, receiver operating characteristic; CI, confidence interval; IQR, inter-quartile range; Q1, lower quartile; Q3, upper quartileBack to article page