From: What’s the cut-point?: a systematic investigation of tau PET thresholding methods
Method | Cut-point | T+ rate | CSF p-tau Cohen’s d | MMSE Cohen’s d | Logical memory Cohen’s d |
---|---|---|---|---|---|
Entorhinal/ROC/A− CU | 1.97 | 32.5% | − .80 (95% CI [− 1.15, −.80]) | 1.14 (95% CI [.87, 1.40]) | 1.17 (95% CI [.90, 1.44]) |
Entorhinal/ROC/CU | 1.94 | 37.6% | − 1.00 (95% CI [− 1.35, −.65]) | 1.12 (95% CI [.85, 1.38]) | 1.12 (95% CI [.86, 1.38]) |
Entorhinal/2SD/A− CU | 2.39 | 21.5% | −.96 (95% CI [−.1.39, −.52]) | 1.65 (95% CI [1.32, .1.97]) | 1.65 (95% CI [1.33, 1.97]) |
Entorhinal/2SD/CU | 2.45 | 19.7% | − 1.06 (95% CI [− 1.50, −.61]) | 1.55 (95% CI [1.22, 1.87]) | 1.54 (95% CI [1.21, 1.86]) |
Meta-ROI/ROC/A− CU | 1.64 | 38.7% | − 1.18 (95% CI [− 1.54, −.82]) | 1.13 (95% CI [.86, 1.39]) | .90 (95% CI [.65, 1.16]) |
Meta-ROI/ROC/CU | 1.68 | 32.8% | − 1.26 (95% CI [− 1.63, −.89]) | 1.25 (95% CI [.97, 1.52]) | .99 (95% CI [.72, 1.25]) |
Meta-ROI/2SD/A−CU | 1.78 | 22.2% | −.1.81 (95% CI [−.2.26, −.1.35]) | 1.67 (95% CI [1,34, 1.98]) | 1.53 (95% CI [1.21, 1.84]) |
Meta-ROI/2SD/CU | 2.08 | 13.9% | − 1.27 (95% CI [− 1.80, −.74] | 1.67 (95% CI [1.30, 2.04]) | 1.42 (95% CI [1.06, 1.79]) |