Fig. 4

Group comparison of cortical thickness and cortical mean diffusivity between participants with GRN mutation and healthy controls. Statistically significant results between PPA participants with GRN mutation (n = 5) and healthy controls for cortical thickness (left) and cortical mean diffusivity (right). For these analyses, we only considered healthy controls scanned at the same MRI than PPA participants with GRN mutation (n = 38). Cortical thickness analyses were adjusted for age, sex, handedness, and MRI scan. Cortical mean diffusivity analyses were adjusted for age, sex, and handedness after a harmonization step. Only effect sizes (Cohen’s d) inside clusters that survived family-wise error correction (P<.05) are shown