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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model

Fig. 1

β3AR stimulation improves peripheral glucose metabolism in NonTg and 3xTg-AD mice. a Schematic description of the experimentation. b Body weight of the mice measured before and during the 1-month experiment (before each i.p. injection) and c at the end of the experiment. d Food consumed per day per mice 3 weeks before and over the 1-month treatment and e area under curve of food consumption over the 1-month treatment measured by weighting the diet every 4 days. f Leptin measured in plasma of fasted mice by ELISA. g GTT consists in measuring the blood glucose in fasted mice for 6-h after a bolus injection of glucose (1 g/kg i.p.). GTT was performed after 3 weeks of experiment and h area under curve of the GTT. i Fasting blood glucose and j plasmatic insulin measured during the GTT with a glucometer or by ELISA, respectively. i Triglycerides measured in the plasma sampled at the end of the experiment. Data are represented as mean ± SEM (n/group indicated in graphs). Statistics: Two-way ANOVA, effect of treatment: **p < 0.01; ****p < 0.0001; effect of genotype: &p < 0.05; &&p < 0.01; &&&&p < 0.0001 (c, f, h, i, j). Kruskal-Wallis, Dunn’s post hoc test: @p < 0.05; @@p < 0.01 (e). Abbreviations: 3xTg-AD: triple transgenic mice; CL: CL-316,243-injected group; DL: dark-light emergence test; GTT: glucose tolerance test; NonTg: non-transgenic mice; NOR: novel object recognition test; OF: open field; S: saline-injected group

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