Skip to main content

Table 3 Frequencies of eligible candidates for clinical trial screening by year of birth and gender

From: The role of sex and gender in the selection of Alzheimer patients for clinical trial pre-screening

All/YOB-gender (N)

Age

Comorbidity

Medication

MMSE

Education

All criteria

< 1925 (748)

97 (13%)

295 (39%)

435 (58%)

694 (93%)

321 (43%)*

10 (1%)

 Men (160)

22 (14%)

57 (36%)

86 (54%)

149 (93%)

93 (58%)

2 (1%)

 Women (588)

75 (13%)

238 (40%)

349 (59%)

545 (93%)

228 (39%)

8 (1%)

 OR [95%CI]

1.18 [0.70–1.99]

0.84 [0.58–1.22]

0.80 [0.56–1.15]

1.02 [0.50–2.05]

2.21 [1.54–3.16]

0.92 [0.19–4.36]

1925–1934 (3912)

2912 (74%)

1489 (38%) *

2486 (64%)

3772 (96%)

1985 (51%)*

426 (11%)

 Men (1163)

873 (75%)

408 (35%)

750 (64%)

1131 (97%)

771 (66%)

144 (12%)

 Women (2749)

2,039 (74%)

1081 (39%)

1736 (63%)

2641 (96%)

1,214 (44%)

282 (10%)

 OR [95%CI]

1.11 [0.94–1.30]

0.79 [0.68–0.92]

1.05 [0.90–1.22]

1.14 [0.76–1.72]

2.51 [2.17–2.90]

1.24 [1.00–1.53]

1935–1944 (3230)

3230 (100%)

1278 (40%) *

2115 (65%)

3148 (97%)

2,047 (63%)*

611 (19%)*

 Men (1019)

1016 (100%)

383 (38%)

690 (68%)

998 (98%)

760 (75%)

215 (21%)

 Women (2211)

2211 (100%)

895 (40%)

1425 (64%)

2150 (97%)

1287 (58%)

396 (18%)

 OR [95%CI]

1.00 [na]

0.84 [0.72–0.98]

1.13 [0.96–1.33]

1.14 [0.69–1.90]

2.11 [1.79–2.49]

1.23 [1.02–1.48]

1945–1959 (1492)

1091 (100%)

657 (44%)

1003 (67%)

1451 (97%)

1238 (83%)*

383 (26%)

 Men (524)

524 (100%)

234 (45%)

364 (69%)

511 (98%)

465 (89%)

136 (26%)

 Women (968)

967 (100%)

423 (44%)

639 (66%)

940 (97%)

773 (80%)

247 (26%)

 OR [95%CI]

1.00 [ na]

1.02 [0.82–1.26]

1.14 [0.90–1.43]

1.12 [0.57–2.20]

1.97 [1.44–2.69]

1.02 [0.80–1.30]

1960+ (211)

144 (68%)

72 (34%)

111 (53%)

204 (97%)

198 (94%)

21 (13%)

 Men (60)

42 (70%)

24 (40%)

35 (58%)

57 (95%)

55 (92%)

9 (15%)

 Women (151)

102 (68%)

48 (32%)

76 (50%)

147 (97%)

143 (95%)

19 (13%)

 OR [95%CI]

1.13 [0.58–2.20]

1.36 [0.72–2.54]

1.32 [0.72–2.44]

0.73 [0.10–5.39]

0.72 [0.15–3.37]

1.23 [0.52–2.89]

  1. YOB, year of birth; MMSE, mini-mental state examination
  2. Unless otherwise noted, data are absolute frequency (relative frequency %)
  3. Asterisk (*) indicate p < 0.05 in test comparing eligibility between males and females by multivariable logistic regression (or univariable logistic regression for all criteria)