Table 1 Inclusion and exclusion criteria for the diagnosis of MCI used in five studies
Eligibility | Inclusion | Exclusion | |||||
|---|---|---|---|---|---|---|---|
Age | MMSE | Other, medication | Functional impairment | Cognitive impairment | Depression | Other/vascular | |
ADNI | 55–90 | 24–30 | Stable medication, AChEIs, memantine admitted, 6 grades education or work history | No functional impairment, but many with high FAQ scores. CDR=0.5; memory ≥ 0.5 | Memory complaint LogMem II, dependent on education | Geriatric Depression Scale ≥6 | Hachinski Ischemic Score IS >5 |
NACC | -- | -- | Similar to ADNI | Essentially normal daily functions | Cognitive complaint, cognitive decline (clinician's diagnosis) | Not specified | Not specified |
InDDEx | 55–85 | -- | No AChEI in previous 2 weeks, no rivastigmine in previous 4 weeks | Cognitive symptoms (not specified); CDR=0.5 | NYU delayed paragraph recall<9 | HDRS>12, HDRS item1 > 1, DSM-IV major depression | AD criteria from DSM-IV or NINCDS-ADRDA mod. Hachinski Ischemic Score>4 |
CNG | ≥ 50 | ≥ 20 | A broader definition of MCI was used | Complaint of cognitive deficit in daily living; minor changes were tolerated: B-ADL< 4 | Decline of cog. abilities (>1 SD) in at least one neuropsychological domain | Not specified | Not specified |
BS-MC | N/A | N/A | Consecutively referred patients from GPs | Essentially Winblad et al. [26] criteria; no significant functional decline | Impairment (≤ −1.28 SD; age-, education-,and gender-adjusted) in ≥ one cognitive domain | Probable cause for MCI other than early AD, based on comprehensive medical exam and neuroimaging results | Not specified |