Table 5 Associations between abdominal circumference across adulthood, and global WMHV, β-amyloid status and brain volumes at age 71
From: Investigating the relationship between BMI across adulthood and late life brain pathologies
Relative change in WMHV (95% CI) | β-amyloid adjusted OR (95% CI) | WBV β coefficient (95% CI) | Mean HV β coefficient (95% CI) | |
|---|---|---|---|---|
Model 3 | Model 3 | Model 3 | Model 3 | |
36 years WMHV: Model 3: n = 409 Amyloid: Model 3: n = 412 WBV/HV: Model 3: n = 401 | 0.91 (0.81, 1.02) | 1.08 (0.80, 1.47) | 4.0 (−1.0, 9.1) | 0.018 (− 0.014, 0.051) |
43 years WMHV: Model 3: n = 425 Amyloid: Model 3: n = 431 WBV/HV: Model 3: n = 417 | 0.95 (0.84, 1.06) | 0.91 (0.66, 1.25) | 2.5 (− 2.7, 7.7) | 0.011 (− 0.022, 0.044) |
53 years WMHV: Model 3: n = 437 Amyloid: Model 3: n = 442 WBV/HV: Model 3: n = 429 | 0.93 (0.84, 1.03) | 0.88 (0.67, 1.15) | 1.5 (− 2.8, 5.9) | 0.003 (− 0.026, 0.032) |
60/64 years WMHV: Model 3: n = 448 Amyloid: Model 3: n = 454 WBV/HV: Model 3: n = 440 | 0.95 (0.87, 1.05) | 0.80 (0.62, 1.03) | 0.0 (− 4.0, 4.0) | 0.007 (− 0.019, 0.033) |
69 years WMHV: Model 3: n = 447 Amyloid: Model 3: n = 449 WBV/HV: Model 3: n = 439 | 0.97 (0.88, 1.06) | 0.83 (0.65, 1.05) | − 1.8 (− 5.5, 2.0) | 0.004 (− 0.020, 0.029) |