From: Investigating the relationship between BMI across adulthood and late life brain pathologies
 | Relative change in WMHV (95% CI) | Adjusted OR for β-amyloid positivity (95% CI) | |||||
---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | ||
Age 36 WMHV: Model 1: n = 415 Model 2: n = 411 Model 3: n = 409 Amyloid: Model 1: n = 418 Model 2: n = 416 Model 3: n = 412 | BMI | 0.99 (0.95, 1.02) | 0.99 (0.95, 1.02) | 0.98 (0.94, 1.02) | 0.99 (0.91, 1.08) | 0.98 (0.89, 1.08) | 0.98 (0.89, 1.08) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.01 (0.78, 1.32) | 1.01 (0.78, 1.30) | 0.95 (0.73, 1.23) | 1.39 (0.78, 2.49) | 1.26 (0.68, 2.33) | 1.23 (0.67, 2.29) | |
Obese | 0.99 (0.54, 1.82) | 0.97 (0.53, 1.78) | 0.95 (0.52, 1.74) | 0.41 (0.05, 3.21) | 0.50 (0.06, 4.14) | 0.48 (0.06, 4.02) | |
Age 43 WMHV: Model 1: n = 434 Model 2: n = 428 Model 3: n = 424 Amyloid: Model 1: n = 438 Model 2: n = 436 Model 3: n = 430 | BMI | 1.01 (0.97, 1.04) | 1.00 (0.97, 1.04) | 1.00 (0.96, 1.03) | 1.00 (0.93, 1.08) | 0.99 (0.92, 1.08) | 0.99 (0.91, 1.08) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.05 (0.84, 1.31) | 1.03 (0.83, 1.29) | 1.01 (0.81, 1.26) | 0.70 (0.41, 1.21) | 0.73 (0.41, 1.28) | 0.72 (0.41, 1.28) | |
Obese | 1.03 (0.68, 1.56) | 0.95 (0.62, 1.45) | 0.94 (0.61, 1.45) | 1.26 (0.51, 3.13) | 1.21 (0.47, 3.12) | 1.26 (0.49, 3.29) | |
Age 53 WMHV: Model 1: n = 444 Model 2: n = 440 Model 3: n = 436 Amyloid: Model 1: n = 448 Model 2: n = 446 Model 3: n = 441 | BMI | 1.00 (0.98, 1.03) | 1.00 (0.97, 1.02) | 0.99 (0.97, 1.02) | 0.98 (0.92, 1.04) | 0.97 (0.91, 1.03) | 0.98 (0.92, 1.05) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.18 (0.94, 1.48) | 1.13 (0.90, 1.41) | 1.10 (0.87, 1.38) | 0.56 (0.33, 0.97) | 0.49 (0.27, 0.88) | 0.51 (0.29, 0.92) | |
Obese | 0.98 (0.73, 1.31) | 0.93 (0.69, 1.25) | 0.90 (0.66, 1.22) | 0.85 (0.44, 1.67) | 0.73 (0.36, 1.48) | 0.89 (0.43, 1.87) | |
Age 60–64 WMHV: Model 1: n = 453 Model 2: n = 452 Model 3: n = 448 Amyloid: Model 1: n = 457 Model 2: n = 455 Model 3: n = 454 | BMI | 1.01 (0.98, 1.03) | 1.01 (0.98, 1.03) | 1.00 (0.98, 1.03) | 0.96 (0.90, 1.02) | 0.95 (0.89, 1.01) | 0.95 (0.89, 1.02) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.11 (0.87, 1.42) | 1.11 (0.88, 1.42) | 1.09 (0.86, 1.40) | 0.89 (0.51, 1.55) | 0.87 (0.48, 1.56) | 0.88 (0.49, 1.59) | |
Obese | 1.17 (0.89, 1.54) | 1.15 (0.88, 1.50) | 1.10 (0.83, 1.45) | 0.68 (0.36, 1.31) | 0.66 (0.33, 1.31) | 0.70 (0.35, 1.40) | |
Age 69 WMHV: Models 1, 2 and 3: n = 446 Amyloid: Model 1: n = 450 Models 2 and 3: n = 448 | BMI | 1.00 (0.98, 1.03) | 1.00 (0.98, 1.03) | 1.00 (0.97, 1.02) | 0.96 (0.90, 1.01) | 0.95 (0.90, 1.01) | 0.95 (0.89, 1.01) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.01 (0.79, 1.29) | 1.02 (0.80, 1.29) | 1.01 (0.79, 1.28) | 0.76 (0.44, 1.32) | 0.78 (0.44, 1.40) | 0.78 (0.44, 1.40) | |
Obese | 1.00 (0.77, 1.32) | 0.99 (0.76, 1.29) | 0.97 (0.74, 1.26) | 0.57 (0.29, 1.09) | 0.55 (0.28, 1.10) | 0.54 (0.27, 1.09) | |
Age 71 WMHV: Model 1: n = 453 Model 2: n = 452 Model 3: n = 448 Amyloid: Model 1: n = 457 Model 2: n = 455 Model 3: n = 454 | BMI | 1.01 (0.98, 1.03) | 1.00 (0.98, 1.03) | 1.00 (0.97, 1.02) | 0.95 (0.90, 1.01) | 0.94 (0.89, 1.00) | 0.95 (0.89, 1.01) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.15 (0.90, 1.47) | 1.14 (0.89, 1.45) | 1.12 (0.88, 1.43) | 0.92 (0.53, 1.60) | 0.86 (0.48, 1.53) | 0.89 (0.49, 1.60) | |
Obese | 1.16 (0.89, 1.53) | 1.12 (0.86, 1.47) | 1.07 (0.82, 1.41) | 0.58 (0.30, 1.13) | 0.55 (0.27, 1.11) | 0.57 (0.28, 1.17) |