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Table 2 Associations between BMI and weight across adulthood, and WMHV and β-amyloid status at age 71

From: Investigating the relationship between BMI across adulthood and late life brain pathologies

 

Relative change in WMHV (95% CI)

Adjusted OR for β-amyloid positivity (95% CI)

Model 1

Model 2

Model 3

Model 1

Model 2

Model 3

Age 36

WMHV:

Model 1: n = 415

Model 2: n = 411

Model 3: n = 409

Amyloid:

Model 1: n = 418

Model 2: n = 416

Model 3: n = 412

BMI

0.99 (0.95, 1.02)

0.99 (0.95, 1.02)

0.98 (0.94, 1.02)

0.99 (0.91, 1.08)

0.98 (0.89, 1.08)

0.98 (0.89, 1.08)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.01 (0.78, 1.32)

1.01 (0.78, 1.30)

0.95 (0.73, 1.23)

1.39 (0.78, 2.49)

1.26 (0.68, 2.33)

1.23 (0.67, 2.29)

Obese

0.99 (0.54, 1.82)

0.97 (0.53, 1.78)

0.95 (0.52, 1.74)

0.41 (0.05, 3.21)

0.50 (0.06, 4.14)

0.48 (0.06, 4.02)

Age 43

WMHV:

Model 1: n = 434

Model 2: n = 428

Model 3: n = 424

Amyloid:

Model 1: n = 438

Model 2: n = 436

Model 3: n = 430

BMI

1.01 (0.97, 1.04)

1.00 (0.97, 1.04)

1.00 (0.96, 1.03)

1.00 (0.93, 1.08)

0.99 (0.92, 1.08)

0.99 (0.91, 1.08)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.05 (0.84, 1.31)

1.03 (0.83, 1.29)

1.01 (0.81, 1.26)

0.70 (0.41, 1.21)

0.73 (0.41, 1.28)

0.72 (0.41, 1.28)

Obese

1.03 (0.68, 1.56)

0.95 (0.62, 1.45)

0.94 (0.61, 1.45)

1.26 (0.51, 3.13)

1.21 (0.47, 3.12)

1.26 (0.49, 3.29)

Age 53

WMHV:

Model 1: n = 444

Model 2: n = 440

Model 3: n = 436

Amyloid:

Model 1: n = 448

Model 2: n = 446

Model 3: n = 441

BMI

1.00 (0.98, 1.03)

1.00 (0.97, 1.02)

0.99 (0.97, 1.02)

0.98 (0.92, 1.04)

0.97 (0.91, 1.03)

0.98 (0.92, 1.05)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.18 (0.94, 1.48)

1.13 (0.90, 1.41)

1.10 (0.87, 1.38)

0.56 (0.33, 0.97)

0.49 (0.27, 0.88)

0.51 (0.29, 0.92)

Obese

0.98 (0.73, 1.31)

0.93 (0.69, 1.25)

0.90 (0.66, 1.22)

0.85 (0.44, 1.67)

0.73 (0.36, 1.48)

0.89 (0.43, 1.87)

Age 60–64

WMHV:

Model 1: n = 453

Model 2: n = 452

Model 3: n = 448

Amyloid:

Model 1: n = 457

Model 2: n = 455

Model 3: n = 454

BMI

1.01 (0.98, 1.03)

1.01 (0.98, 1.03)

1.00 (0.98, 1.03)

0.96 (0.90, 1.02)

0.95 (0.89, 1.01)

0.95 (0.89, 1.02)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.11 (0.87, 1.42)

1.11 (0.88, 1.42)

1.09 (0.86, 1.40)

0.89 (0.51, 1.55)

0.87 (0.48, 1.56)

0.88 (0.49, 1.59)

Obese

1.17 (0.89, 1.54)

1.15 (0.88, 1.50)

1.10 (0.83, 1.45)

0.68 (0.36, 1.31)

0.66 (0.33, 1.31)

0.70 (0.35, 1.40)

Age 69

WMHV:

Models 1, 2 and 3: n = 446

Amyloid:

Model 1: n = 450

Models 2 and 3: n = 448

BMI

1.00 (0.98, 1.03)

1.00 (0.98, 1.03)

1.00 (0.97, 1.02)

0.96 (0.90, 1.01)

0.95 (0.90, 1.01)

0.95 (0.89, 1.01)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.01 (0.79, 1.29)

1.02 (0.80, 1.29)

1.01 (0.79, 1.28)

0.76 (0.44, 1.32)

0.78 (0.44, 1.40)

0.78 (0.44, 1.40)

Obese

1.00 (0.77, 1.32)

0.99 (0.76, 1.29)

0.97 (0.74, 1.26)

0.57 (0.29, 1.09)

0.55 (0.28, 1.10)

0.54 (0.27, 1.09)

Age 71

WMHV:

Model 1: n = 453

Model 2: n = 452

Model 3: n = 448

Amyloid:

Model 1: n = 457

Model 2: n = 455

Model 3: n = 454

BMI

1.01 (0.98, 1.03)

1.00 (0.98, 1.03)

1.00 (0.97, 1.02)

0.95 (0.90, 1.01)

0.94 (0.89, 1.00)

0.95 (0.89, 1.01)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.15 (0.90, 1.47)

1.14 (0.89, 1.45)

1.12 (0.88, 1.43)

0.92 (0.53, 1.60)

0.86 (0.48, 1.53)

0.89 (0.49, 1.60)

Obese

1.16 (0.89, 1.53)

1.12 (0.86, 1.47)

1.07 (0.82, 1.41)

0.58 (0.30, 1.13)

0.55 (0.27, 1.11)

0.57 (0.28, 1.17)

  1. WMHV coefficients represent the relative change in mean WMHV per 1 unit change in BMI or change in weight status using normal weight as the reference group, using GLM. Adjusted β-amyloid ORs are quoted per 1 unit change in BMI or change in weight status using normal weight as the reference group, using logistic regression models. 95% confidence intervals are also shown. Associations significant at p < 0.05 are highlighted in bold. Model numbers are stated in the left-hand column. WMHV models: Model 1 adjusted for TIV, sex and age at scanning; Model 2 also adjusted for contemporaneous SBP; Model 3 also adjusted for adult SEP, DM, hypercholesterolaemia, and smoking status. β-amyloid models: Model 1 adjusted for sex. Model 2 also adjusted for APOE-ε4 status. Model 3 also adjusted for contemporaneous SBP. BMI body mass index, CI confidence interval, DM diabetes mellitus, GLM generalised linear model, REF reference, SBP systolic blood pressure, SEP socioeconomic position, TIV total intracranial volume, WMHV white matter hyperintensity volume