Alzheimer's Research & Therapy

Table 2 Diagnostic value of plasma Nfl and t-tau in the differential diagnosis of neurodegenerative dementias

From: Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease

	Nfl		t-tau
	AUC	95% CI	AUC	95% CI	p value
HC vs. AD	0.97	0.94–0.99	0.67	0.57–0.77	< 0.001
HC vs. CJD	1	1	0.95	0.91–0.98	0.003
HC vs. DLB/PDD	0.95	0.91–0.99	0.57	0.46–0.70	< 0.001
HC vs. FTD	0.81	0.61–1	0.60	0.42–0.80	0.1
HC vs. VaD	0.99	0.99–1	0.55	0.39–0.67	< 0.001
NND vs. AD	0.82	0.70–0.93	0.52	0.37–0.67	< 0.001
NND vs. CJD	0.97	0.94–1	0.91	0.86–0.96	0.05
NND vs. DLB/PDD	0.84	0.72–0.95	0.71	0.57–0.85	0.1
NND vs. FTD	0.66	0.46–0.87	0.69	0.52–0.87	0.7
NND vs. VaD	0.90	0.80–1	0.62	0.45–0.78	0.002
NND-Dem vs. AD	0.95	0.90–1	0.62	0.44–0.80	< 0.001
NND-Dem vs. CJD	0.67	0.53–0.80	0.93	0.89–0.98	< 0.001
NND-Dem vs. DLB/PDD	0.91	0.83–0.99	0.56	0.42–0.77	0.001
NND-Dem vs. FTD	0.97	0.90–1	0.58	0.36–0.79	< 0.001
NND-Dem vs. VaD	0.88	0.78 0.99	0.51	0.32–0.69	0.002
AD vs. CJD	0.98	0.96–1	0.91	0.87–0.96	0.01
AD vs. DLB/PDD	0.62	0.49–0.75	0.72	0.61–0.84	0.3
AD vs. FTD	0.66	0.46–0.85	0.70	0.51–0.88	0.7
AD vs. VaD	0.69	0.56–0.82	0.63	0.48–0.79	0.6
CJD vs. DLB/PDD	0.96	0.93–0.99	0.96	0.92–0.99	0.7
CJD vs. FTD	0.98	0.95–1	0.96	0.92–0.99	0.2
CJD vs. VaD	0.94	0.88–0.99	0.93	0.88–0.98	0.8
DLB/PDD vs. FTD	0.72	0.54–0.90	0.51	0.30–0.70	0.08
DLB/PDD vs. VaD	0.47	0.37–0.68	0.60	0.45–0.75	0.3
FTD vs. VaD	0.82	0.65–0.99	0.63	0.40–0.82	0.1

AUC derived from ROC curves, with 95% CI in the comparative analysis of HC, NND, and NND-Dem vs. neurodegenerative dementia and between the different neurodegenerative dementia groups are indicated. Statistical differences (p values) between AUC values for Nfl and t-tau in the comparisons between pairs of diagnostic groups calculated as explained in the “Statistical analysis” section. AUC, area under the curve; ROC, receiver operating characteristic; 95% CI, 95% confidence interval; HC, healthy controls; NND, neurological diseases without dementia; NND-Dem, neurological diseases with dementia; AD, Alzheimer’s disease; CJD, Creutzfeldt-Jakob disease; DLB/PDD, dementia with Lewy bodies/Parkinson’s disease dementia; FTD, fronto-temporal dementia; VaD, vascular dementia; Nfl, neurofilament light; t-tau, total-tau

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