Fig. 3

Influence of codon 129 PRNP genotype and subtype in plasma Nfl and t-tau in CJD. a Nfl and b t-tau concentrations in CJD stratified by prion protein gene (PRNP) codon 129 genotype (MM, n = 51; MV, n = 11; VV, n = 18). Statistical significance derived from a multi-comparative analysis corrected for covariates for Nfl and t-tau is indicated (linear regression models were used, as explained in the “Statistical analysis” section). Dot plots with mean (line) values are shown. ROC curves for Nfl (c) and t-tau (d) in the comparative analysis of non-CJD-Dem vs. CJD cases stratified by codon 129 PRNP genotype. AUC derived from ROC curves, with 95% CI in the comparative analysis of non-CJD-Dem vs. total CJD cases and CJD cases stratified by codon 129 PRNP genotype are shown. e Nfl and f t-tau concentrations in CJD MM1/MV1 (n = 23) and VV2 (n = 12) subtypes. Statistical significance derived from a comparative analysis corrected for covariates is indicated. Dot plots with mean (line) values are shown. Non-CJD-Dem, non-neurodegenerative dementia; Nfl, neurofilament light; t-tau, total-tau