Fig. 4

Differentially expressed genes in the PFC, striatum, hippocampus and amygdala from APP/PSEN1-Tg mice at 3 and 6 months old. Heatmaps representing the degree of change for the differentially expressed genes at 3 (a, c, e, g) and 6 (b, d, f, h) months between control and APP/PSEN1-Tg (5–6 independent brain samples per area). g The heatmap from the amygdala at 3 months old is a reduced representation from > 100 up- and downregulated genes (p < 0.05;|logFC| > 0.59). Legend (bottom) indicates the colour-coded fold-change scale (− 5 < FC < 5) where negative values represent downregulation in blue, and positive upregulation in red