Skip to main content

Table 3 Sample sizes, minor allele frequency, and imputation quality for the identified variants. MAF minor allele frequency, R-square (Rsq) Imputation quality

From: A novel age-informed approach for genetic association analysis in Alzheimer’s disease

Gene(s)

RS id

Consequence

SNP (hg19)

Discovery

Replication

N

MAF

N

MAF

Rsq

KIF21B

rs2297911

synonymous

1:200959302:G:A

11,006

0.17391

21,631

0.1769

1

USH2A

rs111033333

missense

1:216270469:G:A

11,126

0.00085

19,544

0.00132

0.81

RAB10

rs149622307

synonymous

2:26332640:T:C

11,057

0.00045

9833

0.00076

0.85

TREM2

rs75932628

missense

6:41129252:C:T

11,076

0.00591

21,176

0.00606

0.93

PILRA

rs2405442

synonymous

7:99971313:T:C

11,022

0.29836

21,631

0.30567

0.94

MS4A6A

rs12453

synonymous

11:59945745:T:C

11,114

0.3941

21,481

0.39015

0.99

RIN3

rs150221413

missense

14:93022240:G:T

11,020

0.00082

17,652

0.00131

0.8

TAOK2

rs4077410

synonymous

16:29998200:A:G

11,063

0.47966

21,631

0.48195

0.94

NSF/MAPT/ KANSL1

rs199533

synonymous

17:44828931:G:A

11,094

0.20367

21,631

0.19931

0.99

ABCA7

rs547447016

frameshift

19:1047507:AGGAGCAG:A

11,006

0.00313

18,356

0.00311

0.88