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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: A novel age-informed approach for genetic association analysis in Alzheimer’s disease

Fig. 3

Manhattan plots of exome wide associations in the four main models excluding the APOE region. The age-adjusted logistic regression has no suggestive association (dashed line, p < 1 × 10−5). The main causal variant on TREM2 is exome-wide significant (solid line, p < 5 × 10−7) in the other three models. Among suggestive associations, (i) known AD associations are in red and (ii) novel associations which replicate (p < 0.05) in an independent dataset are in blue (cf Table 3). Colored dots were bootstrapped in the AD-age score model (see the “Methods” section). The minimum p value from the adjustment models for each main model is displayed as in [7]

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