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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: A novel age-informed approach for genetic association analysis in Alzheimer’s disease

Fig. 2

Power of different association models for two specific simulation outcomes. ac A common variant with moderate effect size, evaluated in 1000 cases and 1000 controls at a significance level of α = 0.05, mimicking the condition of common AD cohorts genotyped on SNP arrays. df An uncommon variant with large effect size, evaluated in 5000 cases and 5000 controls at a significance level of α = 5 × 10−7, mimicking the condition of ADSP WES which allows exploration of uncommon and rare variant associations. Panels show power on the y-axis and age-related effect estimates on the x-axis. Outcomes for four models are shown (cf. legend) and the age-related effect estimate for AD [OR (Age-AD)] is marked by a vertical gray dotted line. From left to right, panels show simulation results for increasing mean age differences between cases and controls (cases being younger than controls where applicable)

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