Placebo (group 1) | GV1001 0.56 mg (group 2) | GV1001 1.12 mg (group 3) | Overall | P value | |
---|---|---|---|---|---|
n = 31 | n = 33 | n = 32 | n = 96 | ||
Age (years) | 0.821a | ||||
Mean ± SD | 70.9 ± 8.9 | 70.2 ± 9.8 | 71.6 ± 8.4 | 70.9 ± 9.0 | |
Median | 72.0 | 73.0 | 75.0 | 74.0 | |
Min, Max | 56.0, 84.0 | 56.0, 85.0 | 56.0, 82.0 | 56.0, 85.0 | |
Sex | 0.390b | ||||
Male, n (%) | 12 (38.7) | 10 (30.3) | 15 (46.9) | 37 (38.5) | |
Female, n (%) | 19 (61.3) | 23 (69.7) | 17 (53.1) | 59 (61.5) | |
Age at AD diagnosis (years) | 0.671a | ||||
Mean ± SD | 67.9 ± 8.6 | 66.2 ± 8.3 | 67.8 ± 8.4 | 67.3 ± 8.4 | |
Median | 68.0 | 66.0 | 70.0 | 68.0 | |
Min, Max | 54.0, 82.0 | 53.0, 83.0 | 50.0, 80.0 | 50.0, 83.0 | |
Years since diagnosis of AD | 0.415a | ||||
Mean ± SD | 3.6 ± 1.7 | 4.6 ± 3.9 | 4.4 ± 2.6 | 4.2 ± 2.9 | |
Median | 3.0 | 3.0 | 4.0 | 3.5 | |
Min, Max | 1.0, 8.0 | 0.0, 14.0 | 1.0, 10.0 | 0.0, 14.0 | |
SIB | 0.959a | ||||
Mean ± SD | 75.9 ± 16.5 | 77.3 ± 19.7 | 76.9 ± 20.1 | 76.7 ± 18.7 | |
Median | 81.0 | 85.0 | 84.0 | 83.0 | |
Min, Max | 39.0, 97.0 | 21.0, 97.0 | 15.0, 96.0 | 15.0, 97.0 | |
K-MMSE | 0.618a | ||||
Mean ± SD | 11.9 ± 4.9 | 13.1 ± 5.1 | 12.1 ± 5.3 | 12.4 ± 5.1 | |
Median | 12.0 | 14.0 | 13.0 | 13.0 | |
Min, Max | 4.0, 19.0 | 2.0, 19.0 | 1.0, 19.0 | 1.0, 19.0 | |
CDR-SOB | 0.773a | ||||
Mean ± SD | 10.1 ± 4.1 | 9.5 ± 4.4 | 10.1 ± 4.1 | 9.9 ± 4.2 | |
Median | 10.0 | 9.5 | 10.0 | 10.0 | |
Min, Max | 4.0, 18.0 | 3.0, 22.0 | 5.0, 23.0 | 3.0, 23.0 | |
NPI | 0.077a | ||||
Mean ± SD | 18.8 ± 14.4 | 12.5 ± 12.0 | 22.6 ± 16.7 | 17.9 ± 15.0 | |
Median | 14.0 | 6.5 | 18.0 | 14.0 | |
Min, Max | 1.0, 63.0 | 1.0, 50.0 | 4.0, 68.0 | 1.0, 68.0 | |
GDS | 0.294a | ||||
Mean ± SD | 5.4 ± 0.5 | 5.2 ± 0.4 | 5.3 ± 0.5 | 5.3 ± 0.5 | |
Median | 5.0 | 5.0 | 5.0 | 5.0 | |
Min, Max | 5.0, 6.0 | 5.0, 6.0 | 5.0, 6.0 | 5.0, 6.0 | |
ADCS-ADL | 0.141a | ||||
Mean ± SD | 32.9 ± 9.9 | 38.0 ± 10.6 | 35.8 ± 10.3 | 35.6 ± 10.4 | |
Median | 33.0 | 41.5 | 35.5 | 35.0 | |
Min, Max | 12.0, 54.0 | 10.0, 52.0 | 14.0, 51.0 | 10.0, 54.0 | |
CIBIS | 0.741a | ||||
Mean ± SD | 4.7 ± 0.9 | 4.7 ± 0.7 | 4.8 ± 0.8 | 4.7 ± 0.8 | |
Median | 5.0 | 5.0 | 5.0 | 5.0 | |
Min, Max | 3.0, 6.0 | 3.0, 6.0 | 3.0, 6.0 | 3.0, 6.0 |