Table 1 Operationalization of core and suggestive symptoms and measures of disease burden
Symptom domain | Symptom | Operationalization and cutoff |
|---|---|---|
Core clinical features | Visual hallucinations | QPE visual hallucinations ≥1 |
Parkinsonism | UPDRS: ≥1 on bradykinesia, with ≥1 on rigidity and/or ≥1 on resting tremor subscores | |
RBD | Mayo sleep questionnaire ≥1 | |
Cognitive fluctuations | Clinical assessment of fluctuations ≥5 | |
Suggestive neuropsychiatric symptoms | Depressive symptoms | Geriatric Depression Scale ≥6 |
Apathy | NPI apathy subscale ≥1 | |
Anxiety | NPI anxiety subscale ≥1 | |
Delusions | QPE delusions ≥1 | |
Suggestive autonomic symptoms | Orthostatic hypotension | ≥20 mmHG drop in SBP or ≥10 mmHG drop in DBP |
Constipation | NMSS constipation question (Q21) ≥1 | |
Micturinal problems | NMSS micturinal question (Q22) ≥1 | |
Assessment of disease burden | IADL | Functional Activities Questionnaire (0–30) |
Quality of life | Quality of Life-AD [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52] | |
Caregiver burden | Zarit Caregiver Burden Interview (0–88) |