From: Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease
Adverse effect | Ketogenic diet (n = 26) | Usual diet (n = 26) | ||
---|---|---|---|---|
Week 6 | Week 12 | Week 6 | Week 12 | |
Increased irritability | 9 (35%) | 5 (19%) | 7 (27%) | 9 (35%) |
Increased fatigue | 5 (19%) | 6 (23%) | 2 (8%) | 7 (27%) |
Sugar cravings | 5 (19%) | 2 (8%) | 2 (8%) | 6 (23%) |
Insomnia | 2 (8%) | 1 (4%) | 5 (19%) | 5 (19%) |
Muscle cramps | 5 (19%) | 3 (12%) | 4 (15%) | 1 (4%) |
Constipation | 4 (15%) | 1 (4%) | 2 (8%) | 4 (15%) |
Feeling lightheaded | 1 (4%) | 4 (15%) | 2 (8%) | 3 (12%) |
Increased back pain | 2 (8%) | 1 (4%) | 1 (4%) | 3 (12%) |
Excessive hunger | 1 (4%) | 2 (8%) | 2 (8%) | 0 |
Excessive thirst | 3 (12%) | 1 (4%) | 1 (4%) | 0 |
Nausea | 2 (8%) | 0 | 0 | 2 (8%) |
Headache | 1 (4%) | 0 | 0 | 3 (12%) |
Heartburn | 2 (8%) | 0 | 0 | 2 (8%) |
Diarrhoea | 1 (4%) | 1 (4%) | 0 | 0 |
Palpitations | 0 | 1 (4%) | 0 | 1 (4%) |
Urinary calculus | 0 | 0 | 0 | 1 (4%) |
Gout flare-up | 1 (4%) | 0 | 0 | 0 |
Psychotic episode | 0 | 0 | 0 | 1 (4%) |
Total | 44 | 28 | 28 | 48 |