Table 2 Group comparisons of regional SUVR and brain volumes in P301L MAPT mutation carriers (n = 6) and controls (n = 12). Significant results in bold and italics
From: Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers
Region of interest | FDG-PET imaging: regional SUVR | MR imaging: % of total intracranial volume | ||||||
|---|---|---|---|---|---|---|---|---|
Mutation carriers, mean (SD) | Controls, mean (SD) | U | p | Mutation carriers, mean (SD) | Controls, mean (SD) | U | p | |
Frontal | 1.18 (0.09) | 1.23 (0.08) | 27.00 | 0.44 | 23.38 (0.56) | 22.97 (1.50) | 29.00 | 0.55 |
Temporal | 1.02 (0.09) | 1.04 (0.06) | 31.00 | 0.68 | 13.45 (0.75) | 13.66 (0.48) | 30.00 | 0.60 |
Parietal | 1.09 (0.10) | 1.14 (0.06) | 26.00 | 0.38 | 13.57 (0.72) | 13.71 (0.68) | 35.00 | 0.96 |
Occipital | 1.22 (0.14) | 1.24 (0.10) | 31.00 | 0.68 | 8.51 (0.64) | 8.91 (0.31) | 24.50 | 0.30 |
Insula | 1.22 (0.09) | 1.28 (0.09) | 24.00 | 0.29 | 0.79 (0.06) | 0.74 (0.05) | 18.00 | 0.10 |
Anterior cingulate | 1.25 (0.07) | 1.36 (0.09) | 12.00 | 0.02 | 0.60 (0.06) | 0.68 (0.08) | 14.50 | 0.04 |
Middle cingulate | 1.46 (0.10) | 1.51 (0.08) | 30.00 | 0.62 | 0.61 (0.05) | 0.64 (0.06) | 25.50 | 0.34 |
Posterior cingulate | 1.78 (0.23) | 1.79 (0.15) | 34.00 | 0.89 | 0.68 (0.09) | 0.68 (0.05) | 29.00 | 0.54 |
Hippocampus | 0.96 (0.11) | 0.98 (0.04) | 35.00 | 0.96 | 0.55 (0.02) | 0.55 (0.03) | 35.00 | 0.95 |
Amygdala | 0.75 (0.10) | 0.78 (0.05) | 32.00 | 0.75 | 0.24 (0.01) | 0.24 (0.01) | 35.00 | 0.91 |
Caudate | 1.63 (0.12) | 1.59 (0.11) | 12.00 | 0.57 | 0.48 (0.01) | 0.44 (0.04) | 6.00 | 0.11 |
Putamen | 1.60 (0.13) | 1.67 (0.08) | 13.00 | 0.24 | 0.65 (0.02) | 0.63 (0.05) | 14.00 | 0.30 |
Thalamus | 1.26 (0.13) | 1.30 (0.06) | 19.00 | 0.12 | 0.90 (0.04) | 0.87 (0.06) | 26.00 | 0.38 |