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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Detecting Alzheimer’s disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET

Fig. 3

Voxel-wise results of independent regressions between BHA tests and Flortaucipir PET SUVR. Legend: Left column shows voxel-wise associations between individual BHA tests and Flortaucipir SUVR without covariates. Middle column shows voxel-wise associations between individual BHA tests and Flortaucipir SUVR with inclusion of age as a covariate. Voxel-wise associations are shown at uncorrected P < .001 in blue and at FWE-corrected P < .05 in red. Right column illustrates scatter plots and modeled regression lines (including covariates of CDR Sum of Boxes, clinical phenotype [dummy-coded: 0 = non-amnestic MCI/atypical dementia, 1 = amnestic MCI/amnestic-predominant dementia], and time difference between PET acquisition and BHA completion) on the associations between individual BHA tests and Flortaucipir SUVR in significant clusters at P < .001 uncorrected threshold. Abbreviations: BHA, Brain Health Assessment; CDR-SB, Clinical Dementia Rating Scale Sum of Boxes; FWE, family-wise error; MCI, mild cognitive impairment; PET, positron emission tomography; SUVR, standard uptake value ratio

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