High-intensity exercise and cognitive function in cognitively normal older adults: a pilot randomised clinical trial

Table 3 Changes in cardiorespiratory fitness (residuals) and cognitive function (residuals) from pre- to immediately post-intervention

	Independent variable (F statistic)
Dependent variable^a	High-intensity group	Whole cohort
Dependent variable^a	Fitness change^a	Fitness change^a	Fitness change^a x BDNF Val66Met	Fitness change^a x APOE ε4 carriage
Global Cognition change	4.91*	4.37*	5.13*	2.50
Executive Function change	13.89**	4.83*	4.54*	0.33
Episodic Memory change	0.68	0.84	4.96*	2.57
Attention change	0.94	2.23	0.01	0.13

^aResidualised change scores created from a linear model where the baseline score was entered as an independent variable and post score (6 months) as the dependent variable. *p < 0.05, **p < 0.001. Covariates: age, gender, years of education. Abbreviations: APOE apolipoprotein E, BDNF Val66Met brain-derived neurotrophic factor Valine66Methionine single nucleotide polymorphism

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