Fig. 3

DOCK4 locus. Evidence that supports rs144867634 being the causal variant for the pleiotropic signal at the DOCK4 locus. a In silico evidence that rs144867634 alters DOCK4 splicing. The variant is at the splice junction and is predicted to alter splicing by Human Splice Finder 3 (HSP3) and ASVIPA. b Single-cell mouse kidney data show that Dock4 is expressed by proximal convoluted tubule cells (PT) (128 PT cells of 26,482 assayed have clear evidence of expressing Dock4) and distal convoluted tubule cells (DCT) (27 DCT cells of 8544 assayed have clear evidence of expressing Dock4) (Park et al. 2018). c Mouse brain single-cell data show that Dock4 expression is reduced in microglia when mice have a neuroinflammatory response induced by endotoxin lipopolysaccharide (LPS) injections (Srinvasan et al. 2016)