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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: PET imaging of mGluR5 in Alzheimer’s disease

Fig. 1

mGluR binding ([18F]FPEB BPND) in AD and CN participants measured with [18F]FPEB-PET. a Coronial, axial, and sagittal images of [18F]FPEB parametric PET (BPND) overlaid with T1 MRI scans in a representative CN (top row) and AD (bottom row) participant. The pseudocolor in PET images represents the intensity of [18F]FPEB binding (BPND). Reductions of [18F]FPEB binding are most noticeable in the medial temporal lobe including hippocampus in the AD compared to the CN participants. However, mGluR5 binding appears to be lower in most cortical regions. Comparison of mGluR5 binding in the hippocampus (b) and association cortex (c) between AD and CN participants. AD participants—compared to CN participants—demonstrated significantly lower overall mGluR5 binding (F (1, 31) = 7.4, p = 0.011). In addition, there was a significant diagnostic group × region interaction (F (1, 31) = 9.2, p = 0.0049). Post hoc analyses revealed that hippocampal mGluR5 binding (p = 0.003, t test), but not association cortical mGluR5 binding (p = 0.093), was reduced in AD participants. Error bars represent standard deviations. BPND, binding potential; CN, cognitively normal; AD, Alzheimer’s disease. *p < .05

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