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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study

Fig. 5

Hippocampal volume loss occurs in temporal proximity to tau accumulation. Top, longitudinal trajectories of hippocampal volume (HV, adjusted for intracranial volume) by a age, b neocortical (Neo.) Aβ burden, and c precuneus (PC) tau. Arrowheads in b, c indicate most recent time point; lines are color-encoded by PSEN1 E280a carrier and clinical status according inset legend at top-right. Bottom, Relationships between annualized change in HV and d age, e neo. Aβ change rate, and f PC tau change rate. Inset text gives Spearman correlation and p value within carriers. HV change was marginally associated with and significantly associated with PC tau change rate, but not neo. Aβ change rate, suggesting that loss of HV occurs in temporal proximity to tau accumulation

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Alzheimer's Research & Therapy

ISSN: 1758-9193