Fig. 4

Contemporaneous rates of Aβ and tau accumulation are not correlated among PSEN1 E280a mutation carriers. a Longitudinal trajectories of tau and Aβ burden, expressed as precuneus (PC) Flortaucipir (FTP) standardized uptake value ratio (SUVR) and neocortical (Neo.) Pittsburgh Compound B (PiB) distribution volume ratio (DVR), respectively. Lines and dots are colored by subject group according to inset legend, and arrowhead indicates most recent follow-up time point. b Relationship between baseline Aβ and Aβ change rate, which was quadratic in the full sample (inset text, top left). Linear and quadratic regression fits are shown as dashed and solid gray curves, respectively. c Relationship between baseline Aβ and PC tau change rates. d Relationship between Aβ and PC tau and change rates, expressed as annualized PiB DVR or FTP SUVR change, respectively. e Baseline PC tau vs PC tau change rate. Linear and quadratic regression fits are shown as dashed and solid gray curves, respectively. f Baseline PC tau vs Aβ change rate