Skip to main content
Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study

Fig. 2

Longitudinal Aβ and tau PET images in PSEN1 E280A carriers. Top left: Matrix showing baseline Aβ (PiB DVR) and tau (FTP SUVR) PET measures (color bar) for all subjects: Each column is a PET variable, and each row is a subject, separated by PSEN1 E280A carrier status and ordered by age increasing from top to bottom (right labels; expected age at symptom onset in carriers = 44 years, 95% CI [43–45]). Bottom left: Matrix showing annualized Aβ and tau PET change rates (color bar) for all subjects, arranged as above. Horizontal thick black line separates cognitively unimpaired carriers (UC, above line) from cognitively impaired carriers (IC, below line). We assessed Aβ burden in a large neocortical aggregate (Neo.) and tau burden in three primary ROIs: entorhinal cortex (EC), inferior temporal gyrus (IT), and precuneus (PC). Four exemplary cases are labeled (A–D), with corresponding baseline and 2-year follow-up PET slice data shown at right. A–D: Aβ (PiB DVR, left) and tau (FTP SUVR. right) PET images at baseline and 2-year follow-up in coronal (upper) and sagittal (lower) slices for four exemplary cases, labeled in color matrices at left. Age and carrier status are given for each participant (y/o, years old; NC, non-carrier; UC, unimpaired carrier; IC, impaired carrier)

Back to article page