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Table 2 Risk of dementia, AD, and VD based on the TyG index quartiles

From: The insulin resistance by triglyceride glucose index and risk for dementia: population-based study

TyG index

Events (n)

Duration (person-years)

Incidence rate (per 1000 person-years)

Unadjusted

Model 1

Model 2

All-cause dementia

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Q1

26,613

10,089,076.34

2.64

1 (ref.)

1 (ref.)

1 (ref.)

 Q2

32,819

10,074,648.59

3.26

1.23 (1.22, 1.26)

1.03 (1.01, 1.04)

1.04 (1.02, 1.05)

 Q3

38,606

10,066,646.27

3.84

1.45 (1.43, 1.48)

1.05 (1.04, 1.07)

1.07 (1.05, 1.09)

 Q4

44,676

10,041,387.42

4.45

1.69 (1.66, 1.71)

1.11 (1.09, 1.13)

1.14 (1.12, 1.16)

p for trend

   

< 0.001

< 0.001

< 0.001

AD

 Q1

19,705

10,089,076.34

1.95

1 (ref.)

1 (ref.)

1 (ref.)

 Q2

24,354

10,074,648.59

2.42

1.24 (1.21, 1.26)

1.02 (1.00, 1.03)

1.03 (1.01, 1.05)

 Q3

28,661

10,066,646.27

2.85

1.46 (1.43, 1.48)

1.03 (1.01, 1.05)

1.05 (1.03, 1.07)

 Q4

33,298

10,041,387.42

3.32

1.70 (1.67, 1.73)

1.07 (1.06, 1.09)

1.12 (1.09, 1.14)

p for trend

   

< 0.001

< 0.001

< 0.001

VD

   

 Q1

3341

10,089,076.34

0.33

1 (ref.)

1 (ref.)

1 (ref.)

 Q2

4110

10,074,648.59

0.41

1.23 (1.18, 1.29)

1.08 (1.03, 1.13)

1.05 (1.01, 1.10)

 Q3

4779

10,066,646.27

0.47

1.43 (1.37, 1.50)

1.14 (1.09, 1.19)

1.09 (1.05, 1.15)

 Q4

5570

10,041,387.42

0.55

1.68 (1.61, 1.75)

1.25 (1.20, 1.31)

1.18 (1.12, 1.23)

p for trend

   

< 0.001

< 0.001

< 0.001

  1. AD Alzheimer’s disease, VD vascular dementia, TyG triglyceride glucose index, HR hazard ratio, CI confidence interval
  2. Model 1: age, sex
  3. Model 2: age, sex, smoking status, alcohol consumption, physical activity, low income, body mass index (BMI), hypertension, total cholesterol level