Table 2 Comparison of AD-RAI and volumetric brain measures among NC, AD, and FTD groups from NACC

AD-RAI

0.12 (0.20)

0.94 (0.51)

0.97 (0.23)

< 0.001

< 0.001

0.647

Hippocampus

0.45 (0.05)

0.39 (0.09)

0.42 (0.07)

< 0.001

0.446

0.008

Caudate (L)

0.23 (0.02)

0.23 (0.04)

0.21 (0.04)

0.491

0.836

0.040

Frontal lobe (L) atrophy

42.50 (14.40)

42.30 (13.30)

51.30 (14.10)

> 0.999

< 0.001

0.002

Frontal lobe (R) atrophy

40.70 (14.80)

43.40 (12.80)

51.50 (15.30)

0.647

< 0.001

0.001

Occipital lobe (R) atrophy

9.11 (4.82)

12.70 (5.90)

10.00 (5.46)

< 0.001

> 0.999

< 0.001

Frontal lobe (L)

5.56 (0.67)

5.50 (0.51)

5.22 (0.65)

> 0.999

0.001

0.022

Occipital lobe (R)

2.26 (0.31)

2.13 (0.52)

2.36 (0.34)

> 0.999

0.150

0.022

Temporal lobe (L)

3.71 (0.32)

3.30 (0.40)

3.06 (0.76)

< 0.001

< 0.001

0.061

Temporal lobe (R)

3.68 (0.37)

3.30 (0.55)

3.20 (0.71)

< 0.001

< 0.001

0.540

Parietal lobe (L)

2.63 (0.31)

2.42 (0.38)

2.63 (0.38)

< 0.001

> 0.999

< 0.001

Parietal lobe (R)

2.81 (0.42)

2.50 (0.37)

2.86 (0.40)

0.005

0.239

< 0.001

Insular (L)

0.47 (0.05)

0.42 (0.05)

0.36 (0.07)

0.239

< 0.001

< 0.001

Insular (R)

0.48 (0.05)

0.46 (0.05)

0.42 (0.09)

0.103

< 0.001

0.012

QMTA

0.33 (0.07)

0.55 (0.32)

0.52 (0.38)

< 0.001

< 0.001

> 0.999

MTA score

0.25 (1.00)

1.50 (1.50)

1.50 (1.50)

< 0.001

< 0.001

> 0.999