Table 3 Cohort 2. Alzheimer’s disease (AD) group compared to controls, subjective cognitive decline (SCD), mild cognitive impairment (MCI) and non-AD groups combined. p values and Akaike information criterion (AIC) from binary logistic regression models. Area under the curve (AUC), 95% confidence intervals (95% CI) and differences between AUCs measured with DeLong test from receiver operating characteristic (ROC) analysis. APOE stands for presence of at least one APOE ε4 allele
Cohort 2 | p | AIC | AUC | 95%CI | p value for difference with model containing N-224 alone | |
|---|---|---|---|---|---|---|
AD vs. controls, SCD, MCI and non-AD | N-224 | < 0.0001 | 823 | 0.753 | 0.709–0.797 | – |
Age | < 0.0001 | 830.9 | 0.659 | 0.603–0.715 | 0.007 | |
T-tau | < 0.0001 | 632.5 | 0.884 | 0.856–0.912 | < 0.0001 | |
P-tau181 | < 0.0001 | 601.8 | 0.894 | 0.865–0.923 | < 0.0001 | |
N-224+T-tau | < 0.0001 | 666.9 | 0.886 | 0.859–0.913 | < 0.0001 | |
N-224+P-tau181 | < 0.0001 | 651.7 | 0.895 | 0.866–0.924 | < 0.0001 | |
N-224+APOE | < 0.0001 | 807.3 | 0.784 | 0.749–0.820 | ns | |
Aβ42+P-tau181 | < 0.0001 | 593.3 | 0.921 | 0.902–0.940 | < 0.0001 |