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Table 2 AD-PRSs versus log plasma p-tau181 in the total sample and by diagnostic status

From: Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative

 

APOE PRS

Non-APOE PRS

 

Total sample (n = 818)

PRS version

β

SE

95% CI

p

β

SE

95% CI

p

34-SNP PRS

0.19

0.02

0.14–0.23

2e−17

0.06

0.02

0.02–0.10

2e−3

5e−8 PRS

0.19

0.02

0.15–0.23

3e−18

0.08

0.02

0.03–0.12

3e−4

1e−5 PRS

0.18

0.02

0.13–0.22

8e−16

0.05

0.02

0.004–0.09

0.03

PHS*

0.18

0.02

0.13–0.22

7e−15

0.11

0.04

0.03–0.18

8e−3

 

Cogn unimpaired (n = 236)

β

SE

95% CI

p

β

SE

95% CI

p

34-SNP PRS

0.16

0.05

0.05–0.27

3e−3

0.02

0.04

− 0.07 to 0.10

0.7

5e−8 PRS

0.20

0.05

0.09–0.31

3e−4

0.08

0.04

− 0.003 to 0.17

0.06

1e−5 PRS

0.18

0.06

0.07–0.28

2e−3

0.04

0.05

− 0.05 to 0.13

0.4

PHS*

0.19

0.06

0.08–0.30

1e−3

0.13

0.10

− 0.08 to 0.33

0.2

 

MCI (n = 434)

β

SE

95% CI

p

β

SE

95% CI

p

34-SNP PRS

0.21

0.03

0.15–0.27

8e−13

0.09

0.03

0.04–0.15

1e−3

5e−8 PRS

0.21

0.03

0.15–0.26

2e−12

0.08

0.03

0.03–0.14

1e−4

1e−5 PRS

0.19

0.03

0.14–0.25

4e−11

0.06

0.03

0.004–0.12

0.04

PHS*

0.18

0.03

0.13–0.24

2e−9

0.11

0.06

0.004–0.22

0.04

 

AD (n = 148)

β

SE

95% CI

p

β

SE

95% CI

p

34-SNP PRS

0.13

0.03

0.07–0.19

6e−5

0.03

0.03

− 0.03 to 0.09

0.4

5e−8 PRS

0.12

0.03

0.06–0.18

7e−5

0.03

0.03

− 0.04 to 0.09

0.4

1e−5 PRS

0.13

0.03

0.07–0.19

7e−5

0.03

0.03

− 0.04 to 0.09

0.4

PHS*

0.12

0.03

0.06–0.18

1e−4

0.06

0.05

− 0.04 to 0.15

0.2

  1. Results within the total sample are adjusted for sex, age, principal components, and diagnostic status. Results within the diagnostic groups are adjusted for sex, age, and principal components. Significant p values are shown in bold
  2. *Values presented in the “non-APOE PRS column” are adjusted for ε4-carriership instead of excluding APOE