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Table 2 Demographics and clinical features of FTD syndromes

From: Characteristics and progression of patients with frontotemporal dementia in a regional memory clinic network

 

bvFTD

lvFTD

mFTD

AD

N = 446

N = 118

N = 126

N = 18,831

Variable

Value

NA

p*

Value

NA

p*

Value

NA

p*

Value

NA

Women, n (%)

232 (52.2)

0

< 0.001

68 (57.6)

57.6

0.01

68 (54)

0

< 0.001

13,162 (69.9)

0

Age at first visit, m (sd)

69.4 (10.3)

0

< 0.001

72.7 (9.5)

0

< 0.001

72.0 (8.0)

0

< 0.001

80.6 (7.5)

0

Age at diagnosis, m (sd)

70.2 (10.3)

0

< 0.001

73.6 (9.7)

0

< 0.001

72.8 (8.1)

0

< 0.001

81.0 (7.3)

0

Delay referral (months), m (sd)

40.0 (41.2)

87

< 0.001

30.8 (20.5)

19

0.84

35.8 (29.9)

24

0.13

31.8 (32.0)

5370

Diagnosis wandering (months), m (sd)

9.9 (16.8)

0

< 0.001

10.5 (16.4)

0

< 0.001

9.1 (15.1)

0

< 0.001

5.8 (14.2)

0

Clinical follow-up (months), m (sd)

25.2 (24.0)

0

< 0.001

24.2 (22.0)

0

< 0.001

20.2 (19.6)

0

0,05

17.5 (21.4)

0

Dementia family history, n (%)

75 (16.8)

0

< 0.001

11 (9.3)

0

< 0.001

13 (10.3)

0

< 0.001

508 (2.7)

0

MMSE at first visit, m (sd)

22.1 (6.1)

117

0.02

20.6 (7.5)

27

0.002

21.9 (6.1)

38

< 0.001

18.9 (6.0)

2246

IADL-4, median

3

199

< 0.001

4

38

< 0.001

3

54

< 0.001

2

6689

PET in the network, n (%)

117 (26.2)

0

< 0.001

18 (15.2)

0

< 0,001

25 (19.8)

0

< 0.001

484 (2.5)

0

CSF in the network, n (%)

135 (30.3)

0

< 0.001

22 (18.6)

0

< 0,001

33 (26.2)

0

< 0.001

759 (3.9)

0

Death, n (%)

213 (48.4)

0

 

63 (53.4)

0

 

96 (76.2)

0

 

11,220 (59.1)

0

Survival in years, median

6.5

0

0.18

6.1

0

0.14

4.0

0

< 0.001

5.5

0

Autopsy verification, n (%)

4 (0.8)

0

 

0 (0)

0

 

5 (4.0)

0

 

6 (0.03)

0

  1. AD Alzheimer’s disease, FTD frontotemporal dementia, bvFTD behavioral variant of the frontotemporal dementia, IADL Instrumental Activities of Daily Livings, lvFTD speech variant of the frontotemporal dementia, mFTD motor variant of the frontotemporal dementia, IADL-4 Instrumental Activities of Daily Living—4, MMSE Mini Mental State Examination, m (sd) mean (standard deviation), PET position emission tomography, CSF cerebrospinal Fluid. *Comparison to AD