Skip to main content

Table 1 Subject demographics and clinical characteristics

From: Distinct network topology in Alzheimer’s disease and behavioral variant frontotemporal dementia

  HC (n = 47) AD (n = 50) bvFTD (n = 14) p value
Age (years) 55.47–76.00 (63.20 ± 5.00) 53.58–73.85 (65.45 ± 5.87) 55.44–74.28 (62.05 ± 5.47)
Gender (M/F) 22/25 23/27 3/11
Ethnicity (C/M/I/E/O) 45/0/2/0/0 41/4/2/1/2 11/2/0/1/0
Education (years) 13.47 (3.57) 9.04 (3.84) h 8.79 (2.30) h <.001*
Handedness (R/L/A) 45/1/1 48/0/2 13/1/0
CDR-global 0 (0) 0.76 (0.41) h 0.92 (0.47) h <.001*
MoCA 28.15 (1.59) 17.32 (6.47) h 17.29 (6.66) h <.001*
MMSE 29.02 (1.15) 20.82 (5.66) h 21.21 (6.72) h <.001*
Episodic 0.34 (0.61) −3.80 (1.51) h −2.54 (1.58) ha <.001*
Executive 0.74 (0.34) −1.48 (1.87) h −2.10 (2.23) h <.001*
Attention/working memory 0.38 (0.96) −0.28 (1.03) h −0.63 (1.06) h <.001*
Language 0.53 (0.62) −0.78 (1.46) h −1.65 (1.51) ha <.001*
VisuoSpatial 0.75 (0.79) −0.83 (0.98) h −1.14 (0.89) h <.001*
NPI score 0.45 (1.34) 2.76 (2.80) 9.10 (7.90) ha <.001*
  1. Age is presented as range (mean ± standard deviation), and other items are present as mean (standard deviation). Superscript letters indicate whether group mean was significantly different from HC (h) or AD (a) based on post hoc comparisons (p < 0.05) following one-way ANOVA *Significant at p < 0.05 after Bonferroni correction for multiple comparisons
  2. Abbreviations: HC healthy controls, AD Alzheimer’s disease, bvFTD behavioral variant frontotemporal dementia, M/F male/female, C/M/I/E/O Chinese/Malay/Indian/Eurasian/Others, R/L/A right/left/ambidextrous, CDR-global global Clinical Dementia Rating, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, NPI score total neuropsychiatric inventory severity score
\