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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Distinct network topology in Alzheimer’s disease and behavioral variant frontotemporal dementia

Fig. 1

Study design schematic. We studied the network topological changes in patients with Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) compared to healthy controls (HC) and their association with cognition and behavior. Subject-level functional connectome (FC) was derived from task-free fMRI data based on pairwise Pearson’s correlations between the 141 regions of interests (see “Methods” for details). Graph theoretical nodal-wise metrics including degree centrality and nodal efficiency related to network integration as well as module participation coefficient and within-module degree related to network segregation and distinctiveness were computed for FC. Alterations in functional network topology metrics were compared across groups and subsequently associated with cognition and behavior

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