Table 4 Results for the multivariate linear regression model using baseline and follow-up MMSE scores as the dependent variable

 Dependent variable

R²

Adjusted R²

p

  MMSE baseline score

0.47

0.46

< 0.001

  Baseline independent variables

Unstandardized β coefficient

SE

  Intercept

30.79

2.27

< 0.001

  Age, years

−0.09

0.03

0.003

  Male sex

0.81

0.45

0.07

  Altered MMSE

−6.02

0.48

< 0.001

  ADAM10, ng/mL

−0.1

0.2

0.4

 Dependent variable

R²

Adjusted R²

p

  MMSE follow-up score

0.54

0.53

< 0.001

  Follow-up independent variables

Unstandardized β coefficient

SE

  Intercept

38.97

2.63

< 0.001

  Age, years

− 0.20

0.03

< 0.001

  Male sex

1.52

0.49

0.002

  Altered MMSE

− 6.12

0.52

< 0.001

  ADAM10, ng/mL

− 0.2

0.1

0.06