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Table 1 Baseline and follow-up clinical and demographic parameters of the study population

From: ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study

Variable

Overall (N = 219)

Normal MMSE (n = 151)

Altered MMSE (n = 68)

p

Age, years

   

0.4

 Baseline

69.59 ± 7.07

69.22 ± 6.71

70.43 ± 7.81

 

 Follow-up

72.62 ± 7.11

72.30 ± 6.85

73.31 ± 7.67

 

Female sex

127 (58.0)

86 (57.0)

41 (60.3)

0.7

Schooling

   

0.5

 Illiterate

68 (31.1)

51 (33.8)

17 (25.0)

 

 1–4 years

117 (53.4)

78 (51.7)

39 (57.4)

 

 5–8 years

28 (12.8)

18 (11.9)

10 (14.7)

 

 9+ years

6 (2.7)

4 (2.6)

2 (2.9)

 

Cigarette smoking, yes

   

0.3

 Baseline

122 (55.7)

81 (53.6)

41 (60.3)

 

 Follow-up

119 (54.3)

79 (52.3)

40 (58.8)

 

Alcohol consumption, yes

    

 Baseline

30 (13.7)

20 (13.2)

10 (14.7)

0.8

 Follow-up

33 (15.1)

25 (16.6)

8 (11.8)

0.4

Metabolic syndrome, yes

    

 Baseline

96 (43.8)

65 (43.0)

31 (45.6)

0.5

 Follow-up

89 (40.6)

58 (38.4)

31 (45.6)

0.1

Depression, yes

    

 Baseline

59 (26.9)

37 (24.5)

22 (32.4)

0.2

 Follow-up

61 (27.9)

41 (27.2)

20 (29.4)

0.7

Clock-Drawing test

 Baseline

   

0.1

  Correct

19 (8.7)

17 (11.3)

2 (2.9)

 

  Minimal errors

39 (17.8)

27 (17.9)

12 (17.6)

 

  Major errors

161 (73.5)

107 (70.9)

54 (79.4)

 

 Follow-up

   

0.1

  Correct

28 (12.8)

24 (15.9)

4 (5.9)

 

  Minimal errors

32 (14.6)

22 (14.6)

10 (14.7)

 

  Major errors

159 (72.6)

105 (69.5)

54 (79.4)

 

 MMSE

   

< 0.001

  Baseline

22.21 ± 4.22

24.00 ± 3.12

18.22 ± 3.56

 

  Follow-up

21.68 ± 4.91

22.80 ± 4.20

19.18 ± 5.44

 

 ADAM10, ng/mL

    

  Baseline

1.97 ± 1.0

2.02 ± 1.09

1.87 ± 0.93

0.4

  Follow-up

2.54 ± 2.09

2.49 ± 2.06

2.64 ± 2.16

0.5

  1. Continuous data are presented as mean ± standard deviation or median [interquartile range]. Categorical variables are presented as counts (percentage); MMSE Mini-Mental State Examination