From: ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study
Variable | Overall (N = 219) | Normal MMSE (n = 151) | Altered MMSE (n = 68) | p |
---|---|---|---|---|
Age, years | 0.4 | |||
Baseline | 69.59 ± 7.07 | 69.22 ± 6.71 | 70.43 ± 7.81 | |
Follow-up | 72.62 ± 7.11 | 72.30 ± 6.85 | 73.31 ± 7.67 | |
Female sex | 127 (58.0) | 86 (57.0) | 41 (60.3) | 0.7 |
Schooling | 0.5 | |||
Illiterate | 68 (31.1) | 51 (33.8) | 17 (25.0) | |
1–4 years | 117 (53.4) | 78 (51.7) | 39 (57.4) | |
5–8 years | 28 (12.8) | 18 (11.9) | 10 (14.7) | |
9+ years | 6 (2.7) | 4 (2.6) | 2 (2.9) | |
Cigarette smoking, yes | 0.3 | |||
Baseline | 122 (55.7) | 81 (53.6) | 41 (60.3) | |
Follow-up | 119 (54.3) | 79 (52.3) | 40 (58.8) | |
Alcohol consumption, yes | ||||
Baseline | 30 (13.7) | 20 (13.2) | 10 (14.7) | 0.8 |
Follow-up | 33 (15.1) | 25 (16.6) | 8 (11.8) | 0.4 |
Metabolic syndrome, yes | ||||
Baseline | 96 (43.8) | 65 (43.0) | 31 (45.6) | 0.5 |
Follow-up | 89 (40.6) | 58 (38.4) | 31 (45.6) | 0.1 |
Depression, yes | ||||
Baseline | 59 (26.9) | 37 (24.5) | 22 (32.4) | 0.2 |
Follow-up | 61 (27.9) | 41 (27.2) | 20 (29.4) | 0.7 |
Clock-Drawing test | ||||
Baseline | 0.1 | |||
Correct | 19 (8.7) | 17 (11.3) | 2 (2.9) | |
Minimal errors | 39 (17.8) | 27 (17.9) | 12 (17.6) | |
Major errors | 161 (73.5) | 107 (70.9) | 54 (79.4) | |
Follow-up | 0.1 | |||
Correct | 28 (12.8) | 24 (15.9) | 4 (5.9) | |
Minimal errors | 32 (14.6) | 22 (14.6) | 10 (14.7) | |
Major errors | 159 (72.6) | 105 (69.5) | 54 (79.4) | |
MMSE | < 0.001 | |||
Baseline | 22.21 ± 4.22 | 24.00 ± 3.12 | 18.22 ± 3.56 | |
Follow-up | 21.68 ± 4.91 | 22.80 ± 4.20 | 19.18 ± 5.44 | |
ADAM10, ng/mL | ||||
Baseline | 1.97 ± 1.0 | 2.02 ± 1.09 | 1.87 ± 0.93 | 0.4 |
Follow-up | 2.54 ± 2.09 | 2.49 ± 2.06 | 2.64 ± 2.16 | 0.5 |