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Table 1 Baseline and follow-up clinical and demographic parameters of the study population

From: ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study

Variable Overall (N = 219) Normal MMSE (n = 151) Altered MMSE (n = 68) p
Age, years     0.4
 Baseline 69.59 ± 7.07 69.22 ± 6.71 70.43 ± 7.81  
 Follow-up 72.62 ± 7.11 72.30 ± 6.85 73.31 ± 7.67  
Female sex 127 (58.0) 86 (57.0) 41 (60.3) 0.7
Schooling     0.5
 Illiterate 68 (31.1) 51 (33.8) 17 (25.0)  
 1–4 years 117 (53.4) 78 (51.7) 39 (57.4)  
 5–8 years 28 (12.8) 18 (11.9) 10 (14.7)  
 9+ years 6 (2.7) 4 (2.6) 2 (2.9)  
Cigarette smoking, yes     0.3
 Baseline 122 (55.7) 81 (53.6) 41 (60.3)  
 Follow-up 119 (54.3) 79 (52.3) 40 (58.8)  
Alcohol consumption, yes     
 Baseline 30 (13.7) 20 (13.2) 10 (14.7) 0.8
 Follow-up 33 (15.1) 25 (16.6) 8 (11.8) 0.4
Metabolic syndrome, yes     
 Baseline 96 (43.8) 65 (43.0) 31 (45.6) 0.5
 Follow-up 89 (40.6) 58 (38.4) 31 (45.6) 0.1
Depression, yes     
 Baseline 59 (26.9) 37 (24.5) 22 (32.4) 0.2
 Follow-up 61 (27.9) 41 (27.2) 20 (29.4) 0.7
Clock-Drawing test
 Baseline     0.1
  Correct 19 (8.7) 17 (11.3) 2 (2.9)  
  Minimal errors 39 (17.8) 27 (17.9) 12 (17.6)  
  Major errors 161 (73.5) 107 (70.9) 54 (79.4)  
 Follow-up     0.1
  Correct 28 (12.8) 24 (15.9) 4 (5.9)  
  Minimal errors 32 (14.6) 22 (14.6) 10 (14.7)  
  Major errors 159 (72.6) 105 (69.5) 54 (79.4)  
 MMSE     < 0.001
  Baseline 22.21 ± 4.22 24.00 ± 3.12 18.22 ± 3.56  
  Follow-up 21.68 ± 4.91 22.80 ± 4.20 19.18 ± 5.44  
 ADAM10, ng/mL     
  Baseline 1.97 ± 1.0 2.02 ± 1.09 1.87 ± 0.93 0.4
  Follow-up 2.54 ± 2.09 2.49 ± 2.06 2.64 ± 2.16 0.5
  1. Continuous data are presented as mean ± standard deviation or median [interquartile range]. Categorical variables are presented as counts (percentage); MMSE Mini-Mental State Examination
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