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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Trichostatin A ameliorates Alzheimer’s disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice

Fig. 2

TSA treatment reduced Aβ level in the hippocampus and plasma of APP/PS1 mice. a Representative images showing Aβ plaques in the hippocampus of mice. Thioflavin S (ThioS), green; 6E10, red; DAPI, blue. Scale bar, 200 μm. b Histograms showing the number of 6E10-positive Aβ plaques in the hippocampus (Hip). c Histograms showing the percent area of ThioS-positive Aβ plaques in the hippocampus (Hip). n = 6 per group. d, e Simoa assay for the levels of Aβ40 and Aβ42 in the hippocampus (Hip) (d) and plasma (e) of APP/PS1 mice treated with vehicle or TSA. n = 4 per group. *p < 0.05 and **p < 0.01

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