Skip to main content
Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease

Fig. 4

Metabolite associations with participant age. Plots presenting metabolite concentration change in association with participant age. The plots were fitted with a linear regression model. Plots are shown for the metabolites in the serotonin and kynurenine pathways that reported significant differences between participant groups (Supplementary Figs. S1 and S2). The plots suggest that only serum tryptophan has a negative correlation with age—a major risk factor of AD (r = − 0.1193). The remaining key metabolites all have positive correlation with increased age; however, only serum kynurenine and urine kynurenic acid have a significant positive correlation (serum kynurenine: r = 0.1858, p = 0.0001 (Holm-adjusted p = 0.0009) and kynurenic acid: r = 0.0865, p = 0.0418 (Holm-adjusted p = 0.2089))

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193