Table 3 Fine and Gray sub-distribution hazard ratios (SHR) for incidence of dementia according to APOE genotype, taking into account the competing risk of death

Non-ε4 carrier

4020

4.1

1 (ref.)

–

1 (ref.)

–

ε4 heterozygote

1412

8.4

2.19 (1.73, 2.77)

< 0.001

2.22 (1.75, 2.81)

< 0.001

ε4 homozygote

129

18.6

5.97 (3.85, 9.28)

< 0.001

6.24 (3.99, 9.77)

< 0.001

ε2ε2/ε2ε3

724

3.7

0.81 (0.54, 1.21)

0.30

0.82 (0.54, 1.23)

0.33

ε3ε3

3296

4.2

1 (ref.)

–

1 (ref.)

–

ε2ε4

139

5.8

1.48 (0.73, 3.00)

0.27

1.51 (0.74, 3.07)

0.25

ε3ε4

1273

8.7

2.17 (1.69, 2.78)

< 0.001

2.21 (1.72, 2.83)

< 0.001

ε4ε4

129

18.6

5.75 (3.69, 8.98)

< 0.001

6.01 (3.82, 9.46)

< 0.001