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Table 1 Baseline characteristics overall and by APOE genotype

From: The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

Sample characteristics

APOE genotype

p value

All

ε2ε2

ε2ε3

ε3ε3

ε2ε4

ε3ε4

ε4ε4

(n = 5561)

(n = 33)

(n = 691)

(n = 3296)

(n = 139)

(n = 1273)

(n = 129)

Age, years, mean (SD)

55.5 (5.9)

56.4 (5.6)

55.8 (6.2)

55.6 (5.9)

55.1 (5.9)

55.5 (6.0)

55.1 (6.0)

0.64

Women, n (%)

1508 (27.1)

10 (30.3)

175 (25.3)

930 (28.2)

33 (23.7)

327 (25.7)

33 (25.6)

0.35

Married/cohabiting, n (%)

4256 (76.5)

25 (75.8)

528 (76.4)

2524 (76.6)

103 (74.1)

977 (76.8)

99 (76.7)

0.99

Education level, n (%)

 Lower secondary school

2384 (42.9)

10 (30.3)

294 (42.6)

1423 (43.2)

47 (33.8)

565 (44.4)

45 (34.9)

 

 Higher secondary school

1524 (27.4)

12 (36.4)

191 (27.6)

920 (27.9)

42 (30.2)

324 (25.4)

35 (27.1)

 

 University degree or higher

1653 (29.7)

11 (33.3)

206 (29.8)

953 (28.9)

50 (36.0)

384 (30.2)

49 (38.0)

0.11

Occupation, n (%)

 Low

557 (10.0)

3 (9.1)

60 (8.7)

336 (10.2)

9 (6.5)

140 (11.0)

9 (7.0)

 

 Intermediate

2418 (43.5)

15 (45.5)

318 (46.0)

1449 (44.0)

70 (50.4)

514 (40.4)

52 (40.3)

 

 High

2586 (46.5)

15 (45.5)

313 (45.3)

1511 (45.8)

60 (43.2)

619 (48.6)

68 (52.7)

0.15

Follow time, years, mean (SD)

20.0 (2.8)

19.8 (3.1)

20.0 (2.8)

20.1 (2.7)

20.0 (2.5)

19.9 (2.9)

19.3 (3.4)

0.007

Cognitive function, mean (SD)

 Reasoning (range 0–65)

48.6 (9.7)

49.2 (10.1)

48.7 (9.5)

48.3 (9.8)

49.4 (9.2)

49.1 (9.4)

48.3 (10.3)

0.29

 Memory (range 0–20)

7.1 (2.3)

8.1 (2.7)

6.8 (2.3)

7.1 (2.3)

6.9 (2.5)

7.1 (2.3)

6.9 (2.4)

0.010

 Phonemic fluency (range 0–35)

17.3 (4.3)

18.8 (4.3)

17.2 (4.4)

17.2 (4.2)

17.1 (4.5)

17.5 (4.5)

16.5 (4.3)

0.03

 Semantic fluency (range 0–35)

16.9 (4.0)

18.5 (4.0)

17.0 (4.2)

16.9 (4.0)

16.8 (3.6)

17.0 (4.0)

16.9 (4.0)

0.45

 Standardized global cognitive score

− 0.0 (1.0)

0.4 (1.2)

− 0.0 (1.0)

− 0.0 (1.0)

− 0.0 (1.0)

0.1 (1.0)

− 0.1 (1.1)

0.10