Sample characteristics | APOE genotype | p value | ||||||
---|---|---|---|---|---|---|---|---|
All | ε2ε2 | ε2ε3 | ε3ε3 | ε2ε4 | ε3ε4 | ε4ε4 | ||
(n = 5561) | (n = 33) | (n = 691) | (n = 3296) | (n = 139) | (n = 1273) | (n = 129) | ||
Age, years, mean (SD) | 55.5 (5.9) | 56.4 (5.6) | 55.8 (6.2) | 55.6 (5.9) | 55.1 (5.9) | 55.5 (6.0) | 55.1 (6.0) | 0.64 |
Women, n (%) | 1508 (27.1) | 10 (30.3) | 175 (25.3) | 930 (28.2) | 33 (23.7) | 327 (25.7) | 33 (25.6) | 0.35 |
Married/cohabiting, n (%) | 4256 (76.5) | 25 (75.8) | 528 (76.4) | 2524 (76.6) | 103 (74.1) | 977 (76.8) | 99 (76.7) | 0.99 |
Education level, n (%) | ||||||||
Lower secondary school | 2384 (42.9) | 10 (30.3) | 294 (42.6) | 1423 (43.2) | 47 (33.8) | 565 (44.4) | 45 (34.9) | |
Higher secondary school | 1524 (27.4) | 12 (36.4) | 191 (27.6) | 920 (27.9) | 42 (30.2) | 324 (25.4) | 35 (27.1) | |
University degree or higher | 1653 (29.7) | 11 (33.3) | 206 (29.8) | 953 (28.9) | 50 (36.0) | 384 (30.2) | 49 (38.0) | 0.11 |
Occupation, n (%) | ||||||||
Low | 557 (10.0) | 3 (9.1) | 60 (8.7) | 336 (10.2) | 9 (6.5) | 140 (11.0) | 9 (7.0) | |
Intermediate | 2418 (43.5) | 15 (45.5) | 318 (46.0) | 1449 (44.0) | 70 (50.4) | 514 (40.4) | 52 (40.3) | |
High | 2586 (46.5) | 15 (45.5) | 313 (45.3) | 1511 (45.8) | 60 (43.2) | 619 (48.6) | 68 (52.7) | 0.15 |
Follow time, years, mean (SD) | 20.0 (2.8) | 19.8 (3.1) | 20.0 (2.8) | 20.1 (2.7) | 20.0 (2.5) | 19.9 (2.9) | 19.3 (3.4) | 0.007 |
Cognitive function, mean (SD) | ||||||||
Reasoning (range 0–65) | 48.6 (9.7) | 49.2 (10.1) | 48.7 (9.5) | 48.3 (9.8) | 49.4 (9.2) | 49.1 (9.4) | 48.3 (10.3) | 0.29 |
Memory (range 0–20) | 7.1 (2.3) | 8.1 (2.7) | 6.8 (2.3) | 7.1 (2.3) | 6.9 (2.5) | 7.1 (2.3) | 6.9 (2.4) | 0.010 |
Phonemic fluency (range 0–35) | 17.3 (4.3) | 18.8 (4.3) | 17.2 (4.4) | 17.2 (4.2) | 17.1 (4.5) | 17.5 (4.5) | 16.5 (4.3) | 0.03 |
Semantic fluency (range 0–35) | 16.9 (4.0) | 18.5 (4.0) | 17.0 (4.2) | 16.9 (4.0) | 16.8 (3.6) | 17.0 (4.0) | 16.9 (4.0) | 0.45 |
Standardized global cognitive score | − 0.0 (1.0) | 0.4 (1.2) | − 0.0 (1.0) | − 0.0 (1.0) | − 0.0 (1.0) | 0.1 (1.0) | − 0.1 (1.1) | 0.10 |