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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

Fig. 2

Global cognitive score over the adult life course as a function of number of APOE ε4 alleles. Analysis are undertaken using joint models, using age as time scale (age, age2, and age3), and adjusted for sex, marital status, education level, occupation, and their interactions with time. a Global cognitive score trajectories according to the number of APOE ε4 alleles. b Difference in global cognitive score in APOE ε4 homozygotes and heterozygotes compared to non-ε4 carriers. Gray shaded intervals represent 95% confidence intervals of the estimates

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