Table 1 Baseline characteristics of the study population (n = 203) based on clinical diagnosis. Values are listed as the mean (± standard deviation) and dichotomous data as n (%)

Age, year

60 (±9)

67 (±8)

< 0.001

Female

74 (41%)

14 (61%)

0.072

MMSE

28 (±1)

28 (±1)

0.036

APOE ε4 carrier (reported)

61 (34%)

16 (70%)

<  0.001

ε4 homozygotes

51 (84%)

12 (75%)

–

ε4 heterozygotes

10 (16%)

4 (25%)

–

Follow-up duration, y

2.7 (±2.1)

–

–

Time to progression, y

–

2.5 (±2.2)

–

CSF Aβ₄₂, pg/ml

1053 (±246)

800 (±203)

<  0.001

Plasma Aβ₄₀, pg/ml

208 (± 36)

203 (±34)

0.346

Plasma Aβ₄₂, pg/ml

10 (±2)

9 (±2)

0.003

Plasma Aβ_42/40 ratio

49 (±7)

44 (±7)

0.002