Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice

Table 2 Correlation analysis between levels of A11 immunoreactivity and odor-induced Ca²⁺ activity at the angle-matched olfactory synapse

Parameter	Group A	L	A	E	Group B	G	AP	HA	H
Number of XY pairs	180	180	180	180	180	180	180	180	180
Spearman’s rho	0.5951	0.3453	0.5132	0.4722	− 0.4434	− 0.1664	− 0.2983	− 0.4641	− 0.5803
95% confidence interval	− 0.6849 to − 0.4897	− 0.4710 to − 0.2058	− 0.6159 to − 0.3934	− 0.5811 to − 0.3466	0.3141 to 0.5565	0.01672 to 0.3809	0.1551 to 0.4292	0.3375 to 0.5743	0.4713 to 0.6719
P value (two-tailed)	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	0.0251	< 0.0001	< 0.0001	< 0.0001
P value summary	***	***	***	***	***	*	***	***	***
Exact or approximate P value?	Gaussian approximation	Gaussian approximation	Gaussian approximation	Gaussian approximation	Gaussian approximation	Gaussian approximation	Gaussian approximation	Gaussian approximation	Gaussian approximation
Is the correlation significant? (alpha = 0.05)	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes

Data represent the relationship between A11 immunoreactivity and odor-induced Ca²⁺ activity at the angle-matched olfactory synapse (Fig. S4). The experimental odorants included lyral [L], eugenol [E], acetophenone [A], geraniol [G], ally phenylacetate [AP], heptanoic acid [HA], and heptanal [H]. For the statistical analysis, a non-parametric Spearman’s correlation was performed, followed by linear regression with a 95% confidence interval. Statistical significances are denoted as follows: non-significant (ns); *P < 0.05; ***P < 0.001

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