Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice

Table 1 Ca²⁺ activation in the peripheral olfactory glomeruli

Unpaired *t test*	L	A	E	G	AP	HA	H
P value (two-tailed)	0.2271	0.8298	0.9171	< 0.0001	< 0.0001	< 0.0001	< 0.0001
P value summary	ns	ns	ns	***	***	***	***
T	1.287	0.2207	0.1067	8.422	9.916	12.53	9.448
Df	10	10	10	10	10	10	10
Are means significantly different? (P < 0.05)	No	No	No	Yes	Yes	Yes	Yes

Data are represented as a numerical value representing the odor-derived Ca²⁺ activity between WT and 5xFAD mice (Fig. 2f, h). The experimental odorants included lyral [L], eugenol [E], acetophenone [A], geraniol [G], ally phenylacetate [AP], heptanoic acid [HA], and heptanal [H]. Alzheimer’s disease (AD), five familial AD mutations (5xFAD). For the statistical analysis, a two-tailed unpaired t test was performed. Statistical significances are denoted as follows: non-significant (ns); ***P < 0.001

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