Fig. 4

Increased A11 immunoreactivity and decreased odor Ca²⁺ activity in the ventral glomeruli of 5xFAD. a, b Scatter plots with Spearman’s correlations among the degree of glomeruli (°), A11 immunoreactivity (intensity), and odor Ca²⁺ activity in the olfactory glomeruli in WT (a) compared with 5xFAD (b) mice. Scatter diagrams displaying correlations between each variation, linear regression analysis with 95% confidence intervals was used (gray dashed line). Dot and line showing odor Ca²⁺ activity indicated in orange (group A) and purple (group B), and A11 immunoreactivity data indicated in red dots and line. Wild-type (WT), five familial AD mutations (5xFAD), Alzheimer’s disease (AD)