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Table 2 Characteristics of the study population and subgroups in total and stratified by amyloid-PET status

From: Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis

 

Study population

CN subgroup

aMCI subgroup

Total

Aβ−

Aβ+

Total

Aβ−

Aβ+

Total

Aβ−

Aβ+

Number (%)

199

161 (81)

38 (19)

161

137 (85)

24 (15)

38

24 (63)

14 (37)

Mean age (SD), years

70 (6)

69 (6)

72 (5)b

69 (6)

69 (6)

71 (5)

71 (7)

69 (6)

74 (6)

Female, n (%)

89 (45)

72 (45)

17 (45)

73 (45)

61 (45)

12 (50)

16 (42)

11 (46)

5 (36)

Mean education (SD), years

14 (3)

14 (3)

14 (4)

14 (3)

14 (3)

14 (4)

14 (4)

14 (4)

14 (3)

APOE-ε4 carriers/homozygous, n (%)

92/7 (46)

70/5 (43)

22/2 (58)

82/6 (51)

65/5 (47)

17/1 (71)a

10/1 (26)

5/0 (21)

5/1 (36)

Median MMSE (IQR), /30

29 (2)

29 (2)

29 (2)a

29 (2)

29 (2)

29 (2)

29 (2)

29 (1)

27 (3)a

Median ELISA plasma Aβ1–42/Aβ1–40 (IQR)

0.17 (0.03)

0.18 (0.03)

0.15 (0.02)d

0.18 (0.03)

0.18 (0.03)

0.15 (0.02)d

0.17 (0.02)

0.18 (0.03)

0.16 (0.01)b

Median ELISA plasma Aβ1–42/t-tau (IQR)

1.23 (0.50)

1.32 (0.49)

1.00 (0.29)d

1.25 (0.49)

1.29 (0.49)

1.02 (0.34)c

1.21 (0.58)

1.41 (0.51)

0.89 (0.27)d

Median SIMOA plasma Aβ1–42/Aβ1–40 (IQR)

0.26 (0.06)

0.26 (0.06)

0.21 (0.05)d

0.26 (0.06)

0.26 (0.05)

0.21 (0.05)d

0.24 (0.07)

0.28 (0.06)

0.22 (0.03)c

Median SIMOA plasma Aβ1–42/t-tau (IQR)

0.93 (0.41)

0.99 (0.39)

0.73 (0.24)d

0.94 (0.37)

0.99 (0.38)

0.74 (0.27)c

0.92 (0.45)

1.14 (0.33)

0.70 (0.21)d

  1. aMCI amnestic mild cognitive impairment, β-amyloid, CDR Clinical Dementia Rating, CN cognitively normal, ELISA enzyme-linked immunosorbent assay, IQR interquartile range, MMSE Mini-Mental State Examination, SIMOA single molecule array, t-tau total tau. p values reflect comparisons between Aβ−ve and Aβ+ve groups: ap <  0.05; bp <  0.01; cp <  0.001; dp <  0.0001