From: Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts
Subgroup effect | Baseline estimated marginal means ± SE of subgroup | p values of pairwise comparisons between subgroups | Time effect | Subgroup x Time | Estimated slopes ± SE of subgroup | p value of pairwise comparisons of slope differences between subgroups | ||||||||||||||||||||
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Bio-marker | Cognitive state | Cohort: platform | N per subgroup 1/2/3/4 | p value | Subgroup 1 | Subgroup 2 | Subgroup 3 | Subgroup 4 | 1 vs 2 | 1 vs 3 | 1 vs 4 | 2 vs 3 | 2 vs 4 | 3 vs 4 | p value | p value | Subgroup 1 | Subgroup 2 | Subgroup 3 | Subgroup 4 | 1 vs 2 | 1 vs 3 | 1 vs 4 | 2 vs 3 | 2 vs 4 | 3 vs 4 |
T-tau | NC | ADC: Innotest | 240/73/13/4 | 0.428 | 28.4 ± 0.1 | 28 ± 0.2 | 27.3 ± 0.4 | 23.8 ± 0.9 | 6.45E−02 | 1.07E−02 | 2.00E−07 | 1.15E−01 | 2.20E−06 | 2.54E−04 | 1.14E−07 | 1.34E−05 | 0 ± 0.1 | −0.2 ± 0.1 a | −0.3 ± 0.2 | −2.2 ± 0.5 c | 6.16E−02 | 1.51E−01 | 2.65E−06 | 7.06E−01 | 1.97E−05 | 8.86E−05 |
ADNI: Luminex | 151/151/60/2 | 0.231 | 28.8 ± 0.1 | 28.8 ± 0.1 | 28.6 ± 0.1 | 29.3 ± 0.6 | 8.90E−01 | 1.07E−01 | 5.10E−01 | 7.92E−02 | 5.25E−01 | 3.06E−01 | 3.12E−01 | 3.23E−03 | 0 ± 0 | −0.1 ± 0 b | − 0.3 ± 0 c | 0.1 ± 0.3 | 1.38E−01 | 3.36E−04 | 5.15E−01 | 1.21E−02 | 3.55E−01 | 1.36E−01 | ||
ADNI: Elecsys | 124/163/67/3 | 0.725 | 28.8 ± 0.1 | 28.8 ± 0.1 | 28.6 ± 0.1 | 28.7 ± 0.5 | 7.25E−01 | 1.58E−01 | 8.06E−01 | 2.20E−01 | 8.65E−01 | 8.82E−01 | 9.20E−02 | 1.15E−01 | 0 ± 0 | −0.1 ± 0 b | −0.2 ± 0 c | 0 ± 0.2 | 2.32E−01 | 1.60E−02 | 9.47E−01 | 1.20E−01 | 7.42E−01 | 4.69E−01 | ||
MCI | ADC: Innotest | 199/170/92/4 | 0.270 | 26.6 ± 0.2 | 25 ± 0.2 | 24.2 ± 0.3 | 24.2 ± 1.7 | 7.98E−09 | 1.13E−11 | 1.47E−01 | 2.99E−02 | 6.39E−01 | 9.71E−01 | 2.05E−03 | 8.94E−13 | −0.2 ± 0.1 a | −1.0 ± 0.1 c | − 1.3 ± 0.1 c | −0.6 ± 1 | 2.48E−10 | 3.78E−11 | 6.98E−01 | 1.35E−01 | 6.68E−01 | 5.13E−01 | |
ADNI: Luminex | 162/237/145/56 | 0.0002 | 27.9 ± 0.2 | 26.4 ± 0.2 | 25.1 ± 0.2 | 24 ± 0.4 | 1.36E−06 | 4.46E−16 | 4.12E−17 | 3.32E−05 | 3.80E−08 | 1.39E−02 | 1.74E−47 | 7.39E−17 | −0.2 ± 0.1 a | −0.7 ± 0.1 c | −1.2 ± 0.1 c | − 1.6 ± 0.2 c | 4.68E−05 | 3.56E−13 | 1.82E−14 | 7.80E−05 | 1.39E−07 | 1.69E−02 | ||
ADNI: Elecsys | 145/247/154/41 | 0.0001 | 27.7 ± 0.2 | 26.7 ± 0.2 | 25.1 ± 0.2 | 23.7 ± 0.5 | 9.96E−04 | 2.04E−14 | 4.56E−14 | 1.12E−07 | 3.71E−09 | 9.62E−03 | 7.02E−43 | 7.36E−16 | −0.2 ± 0.1 a | − 0.6 ± 0.1 c | −1.1 ± 0.1 c | − 1.8 ± 0.2 c | 5.03E−04 | 2.90E−11 | 3.83E−14 | 6.21E−05 | 5.28E−09 | 9.50E−04 | ||
AD dementia | ADC: Innotest | 122/303/280/38 | 0.172 | 20.4 ± 0.4 | 19.7 ± 0.3 | 18.9 ± 0.3 | 17.1 ± 0.8 | 1.58E−01 | 3.00E−03 | 1.58E−04 | 3.87E−02 | 1.32E−03 | 2.61E−02 | 1.72E−71 | 1.73E−04 | −1.7 ± 0.2 c | −2.0 ± 0.1 c | −2.3 ± 0.1 c | − 3.5 ± 0.4 c | 1.49E−01 | 1.55E−02 | 1.95E−05 | 2.00E−01 | 1.92E−04 | 1.69E−03 | |
ADNI: Luminex | 13/63/95/43 | 0.031 | 23.9 ± 0.9 | 22 ± 0.4 | 21.6 ± 0.3 | 20.8 ± 0.5 | 5.04E−02 | 1.41E−02 | 2.35E−03 | 4.16E−01 | 5.82E−02 | 1.77E−01 | 3.33E−16 | 1.29E−01 | −1.5 ± 0.8 a | −2.0 ± 0.4 c | − 2.4 ± 0.3 c | − 3.2 ± 0.5 c | 6.20E−01 | 3.06E−01 | 6.60E−02 | 3.67E−01 | 3.53E−02 | 1.34E−01 | ||
ADNI: Elecsys | 13/68/99/28 | 0.008 | 25 ± 0.9 | 21.8 ± 0.4 | 21.3 ± 0.3 | 21.3 ± 0.6 | 1.00E−03 | 1.33E−04 | 6.41E−04 | 3.69E−01 | 4.77E−01 | 9.33E−01 | 8.53E−13 | 3.68E−02 | −0.3 ± 0.8 | −2.2 ± 0.4 c | − 2.4 ± 0.3 c | − 3.0 ± 0.6 c | 2.48E−02 | 9.79E−03 | 4.88E−03 | 6.24E−01 | 2.33E−01 | 3.65E−01 | ||
P-tau | NC | ADC: Innotest | 237/76/15/2 | 0.120 | 28.4 ± 0.1 | 28.2 ± 0.2 | 27.5 ± 0.4 | 22.2 ± 1 | 2.84E−01 | 2.48E−02 | 1.10E−08 | 1.03E−01 | 3.91E−08 | 3.65E−06 | 2.80E−07 | 3.36E−05 | −0.1 ± 0.1 | −0.1 ± 0.1 | −0.2 ± 0.2 | −2.5 ± 0.5 c | 3.79E−01 | 4.50E−01 | 2.05E−06 | 7.62E−01 | 5.29E−06 | 2.55E−05 |
ADNI: Luminex | 137/164/59/3 | 0.883 | 28.9 ± 0.1 | 28.7 ± 0.1 | 28.7 ± 0.1 | 29.1 ± 0.8 | 6.64E−02 | 1.13E−01 | 7.68E−01 | 7.89E−01 | 5.74E−01 | 5.43E−01 | 2.10E−01 | 1.35E−01 | 0 ± 0 | −0.1 ± 0 | −0.2 ± 0.1 b | −0.1 ± 0.4 | 5.87E−02 | 4.56E−02 | 8.32E−01 | 4.88E−01 | 9.82E−01 | 8.85E−01 | ||
ADNI: Elecsys | 206/124/24/2 | 0.367 | 28.8 ± 0.1 | 28.7 ± 0.1 | 28.5 ± 0.2 | 29.2 ± 0.7 | 2.81E−01 | 1.70E−01 | 5.56E−01 | 4.27E−01 | 4.39E−01 | 3.15E−01 | 1.24E−01 | 8.11E−03 | −1.3 ± 0.6 a | −2.1 ± 0.3 c | −2.7 ± 0.4 c | −3.0 ± 0.6 c | 1.74E−01 | 3.60E−02 | 3.29E−02 | 2.52E−01 | 1.83E−01 | 5.96E−01 | ||
MCI | ADC: Innotest | 208/173/79/5 | 0.575 | 26.3 ± 0.2 | 25.1 ± 0.2 | 24.3 ± 0.3 | 23.8 ± 1.4 | 6.13E−05 | 7.46E−08 | 7.69E−02 | 2.19E−02 | 3.41E−01 | 7.18E−01 | 2.94E−09 | 5.39E−08 | −0.4 ± 0.1 c | −0.9 ± 0.1 c | −1.2 ± 0.1 c | −2.0 ± 0.7 b | 1.32E−05 | 1.08E−07 | 2.23E−02 | 6.44E−02 | 1.32E−01 | 2.75E−01 | |
ADNI: Luminex | 164/259/161/12 | 0.009 | 27.7 ± 0.2 | 26.3 ± 0.2 | 25 ± 0.2 | 23.8 ± 0.8 | 1.03E−06 | 8.81E−17 | 8.02E−06 | 1.20E−05 | 4.47E−03 | 1.95E−01 | 2.19E−27 | 3.33E−16 | −0.2 ± 0.1 a | −0.7 ± 0.1 c | −1.3 ± 0.1 c | −2.0 ± 0.3 c | 1.04E−04 | 2.19E−16 | 3.76E−07 | 1.31E−07 | 1.50E−04 | 6.60E−02 | ||
ADNI: Elecsys | 228/224/103/32 | 0.011 | 27.6 ± 0.2 | 26.1 ± 0.2 | 24.6 ± 0.3 | 23.7 ± 0.5 | 6.25E−08 | 3.34E−18 | 1.74E−12 | 8.99E−06 | 1.14E−05 | 1.32E−01 | 1.76E−46 | 5.50E−19 | −0.2 ± 0.1 b | −0.8 ± 0.1 b | −1.4 ± 0.1 c | −1.8 ± 0.2 c | 1.74E−01 | 3.60E−02 | 3.29E−02 | 2.52E−01 | 1.83E−01 | 5.96E−01 | ||
AD dementia | ADC: Innotest | 149/348/216/30 | 0.250 | 20.2 ± 0.4 | 19.4 ± 0.2 | 19 ± 0.3 | 16.3 ± 0.9 | 7.19E−02 | 1.25E−02 | 4.35E−05 | 2.97E−01 | 6.82E−04 | 4.03E−03 | 2.75E−65 | 9.95E−05 | −1.8 ± 0.2 c | −2 ± 0.1 c | −2.4 ± 0.1 c | −3.7 ± 0.4 c | 3.14E−01 | 5.30E−03 | 7.50E−05 | 2.36E−02 | 2.48E−04 | 6.23E−03 | |
ADNI: Luminex | 17/98/83/14 | 0.483 | 23.7 ± 0.8 | 21.5 ± 0.3 | 21.5 ± 0.4 | 21.8 ± 0.9 | 1.21E−02 | 1.30E−02 | 1.20E−01 | 9.54E−01 | 7.47E−01 | 7.26E−01 | 1.62E−10 | 9.00E−02 | −0.7 ± 0.7 | −2.5 ± 0.3 c | −2.6 ± 0.3 c | −2.1 ± 0.8 a | 2.00E−02 | 1.33E−02 | 2.06E−01 | 7.23E−01 | 6.68E−01 | 5.53E−01 | ||
ADNI: Elecsys | 26/91/66/25 | 0.118 | 23.4 ± 0.7 | 21.8 ± 0.3 | 21.2 ± 0.4 | 21.2 ± 0.7 | 3.21E−02 | 4.37E−03 | 1.91E−02 | 2.39E−01 | 4.10E−01 | 9.88E−01 | 1.88E−18 | 9.79E−02 | −1.3 ± 0.6 a | −2.1 ± 0.3 c | −2.7 ± 0.4 c | −3.0 ± 0.6 c | 1.74E−01 | 3.60E−02 | 3.29E−02 | 2.52E−01 | 1.83E−01 | 5.96E−01 |