From: Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts
NC vs AD-type dementia | NC vs MCI | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
First cut-point | Cut-point (literature) | First cut-point | Cut-point (literature) | |||||||
Dataset | First cut-point | Cut-point (literature) | Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity |
T-tau | ||||||||||
ADC: Innotest | 349 | 375a | 0.84 (0.8–0.86) | 0.78 (0.74–0.82) | 0.81 (0.78–0.84) | 0.82 (0.78–0.86) | 0.56 (0.52–0.6) | 0.78 (0.75–0.81) | 0.52 (0.47–0.56) | 0.82 (0.79–0.84) |
ADNI: Luminex | 54 | 93b | 0.95 (0.9–0.98) | 0.4 (0.33–0.48) | 0.64 (0.55–0.72) | 0.81 (0.74–0.86) | 0.73 (0.69–0.76) | 0.42 (0.36–0.47) | 0.35 (0.31–0.39) | 0.81 (0.76–0.84) |
ADNI: Elecsys | 192 | 300c | 0.94 (0.88–0.97) | 0.33 (0.26–0.4) | 0.64 (0.55–0.72) | 0.78 (0.71–0.84) | 0.76 (0.72–0.79) | 0.34 (0.29–0.39) | 0.37 (0.33–0.4) | 0.77 (0.72–0.81) |
P-tau | ||||||||||
ADC: Innotest | 56 | 52a | 0.78 (0.75–0.81) | 0.77 (0.72–0.81) | 0.83 (0.8–0.86) | 0.72 (0.68–0.77) | 0.54 (0.5–0.58) | 0.76 (0.73–0.79) | 0.59 (0.55–0.63) | 0.7 (0.67–0.73) |
ADNI: Luminex | 23 | 23b | 0.9 (0.84–0.95) | 0.4 (0.33–0.47) | 0.9 (0.84–0.95) | 0.4 (0.33–0.48) | 0.72 (0.68–0.76) | 0.37 (0.32–0.42) | 0.72 (0.68–0.76) | 0.37 (0.32–0.43) |
ADNI: Elecsys | 21 | 24c | 0.84 (0.76–0.9) | 0.56 (0.48–0.63) | 0.8 (0.72–0.87) | 0.67 (0.6–0.74) | 0.61 (0.57–0.65) | 0.56 (0.51–0.61) | 0.5 (0.46–0.54) | 0.68 (0.63–0.72) |